Entity Details

Primary name DHE3_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00367
EntryNameDHE3_HUMAN
FullNameGlutamate dehydrogenase 1, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length558
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesGLUD1

GO terms

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GOName
GO:0004352 glutamate dehydrogenase (NAD+) activity
GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
GO:0004354 glutamate dehydrogenase (NADP+) activity
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005783 endoplasmic reticulum
GO:0006537 glutamate biosynthetic process
GO:0006538 glutamate catabolic process
GO:0006541 glutamine metabolic process
GO:0009064 glutamine family amino acid metabolic process
GO:0021762 substantia nigra development
GO:0032024 positive regulation of insulin secretion
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0070403 NAD+ binding
GO:0070728 leucine binding
GO:0072350 tricarboxylic acid metabolic process

Subcellular Location

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Subcellular Location
Endoplasmic reticulum
Mitochondrion

Domains

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DomainNameCategoryType
IPR006095 Glutamate/phenylalanine/leucine/valine dehydrogenaseFamilyFamily
IPR006096 Glutamate/phenylalanine/leucine/valine dehydrogenase, C-terminalDomainDomain
IPR006097 Glutamate/phenylalanine/leucine/valine dehydrogenase, dimerisation domainDomainDomain
IPR033524 Leu/Phe/Val dehydrogenases active siteSiteActive site
IPR033922 NAD(P) binding domain of glutamate dehydrogenaseDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00142 Glutamic acidDrugbanksmall molecule
DB00157 NADHDrugbanksmall molecule
DB00756 HexachloropheneDrugbanksmall molecule
DB04137 Guanosine-5'-TriphosphateDrugbanksmall molecule
DB11081 Aluminum chlorideDrugbanksmall molecule