Entity Details

Primary name ITB7_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP26010
EntryNameITB7_HUMAN
FullNameIntegrin beta-7
TaxID9606
Evidenceevidence at protein level
Length798
SequenceStatuscomplete
DateCreated1992-05-01
DateModified2021-06-02

Ontological Relatives

GenesITGB7

GO terms

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GOName
GO:0001618 virus receptor activity
GO:0003366 cell-matrix adhesion involved in ameboidal cell migration
GO:0005178 integrin binding
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0016477 cell migration
GO:0030198 extracellular matrix organization
GO:0033627 cell adhesion mediated by integrin
GO:0034113 heterotypic cell-cell adhesion
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034669 integrin alpha4-beta7 complex
GO:0038023 signaling receptor activity
GO:0043113 receptor clustering
GO:0043235 receptor complex
GO:0046872 metal ion binding
GO:0050776 regulation of immune response
GO:0050839 cell adhesion molecule binding
GO:0050901 leukocyte tethering or rolling
GO:0070062 extracellular exosome
GO:0072678 T cell migration

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR002369 Integrin beta subunit, VWA domainDomainDomain
IPR012896 Integrin beta subunit, tailDomainDomain
IPR013111 EGF-like domain, extracellularDomainDomain
IPR014836 Integrin beta subunit, cytoplasmic domainDomainDomain
IPR015437 Integrin beta-7 subunitFamilyFamily
IPR015812 Integrin beta subunitFamilyFamily
IPR016201 PSI domainDomainDomain
IPR032695 Integrin domain superfamilyFamilyHomologous superfamily
IPR033760 Integrin beta N-terminalDomainDomain
IPR036349 Integrin beta tail domain superfamilyFamilyHomologous superfamily
IPR036465 von Willebrand factor A-like domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB05122 R1295Drugbanksmall molecule
DB09033 VedolizumabDrugbankbiotech