Entity Details

Primary name RPB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP30876
EntryNameRPB2_HUMAN
FullNameDNA-directed RNA polymerase II subunit RPB2
TaxID9606
Evidenceevidence at protein level
Length1174
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesPOLR2B

GO terms

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GOName
GO:0000398 mRNA splicing, via spliceosome
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003723 RNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005665 RNA polymerase II, core complex
GO:0006283 transcription-coupled nucleotide-excision repair
GO:0006351 transcription, DNA-templated
GO:0006366 transcription by RNA polymerase II
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006370 7-methylguanosine mRNA capping
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0016020 membrane
GO:0016070 RNA metabolic process
GO:0032549 ribonucleoside binding
GO:0042795 snRNA transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048239 negative regulation of DNA recombination at telomere
GO:0050434 positive regulation of viral transcription
GO:0060964 regulation of gene silencing by miRNA

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domainDomainDomain
IPR007121 RNA polymerase, beta subunit, conserved siteSiteConserved site
IPR007641 RNA polymerase Rpb2, domain 7DomainDomain
IPR007642 RNA polymerase Rpb2, domain 2DomainDomain
IPR007644 RNA polymerase, beta subunit, protrusionDomainDomain
IPR007645 RNA polymerase Rpb2, domain 3DomainDomain
IPR007646 RNA polymerase Rpb2, domain 4DomainDomain
IPR007647 RNA polymerase Rpb2, domain 5DomainDomain
IPR014724 RNA polymerase Rpb2, OB-foldFamilyHomologous superfamily
IPR015712 DNA-directed RNA polymerase, subunit 2FamilyFamily
IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamilyFamilyHomologous superfamily
IPR037034 RNA polymerase Rpb2, domain 2 superfamilyFamilyHomologous superfamily

Diseases

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Interactions

50 interactions

InteractorPartnerSourcesPublicationsLink
RPB2_HUMANCTDP1_HUMANBioGRID, HPRD, MINT15670829 details
RPB2_HUMANWWOX_HUMANBioGRID, MINT16055720 24550385 details
RPB2_HUMANRPB4_HUMANBioGRID, HPRD, IntAct, MINT10567706 22939629 24981860 26344197 28514442 details
RPB2_HUMANRPB3_HUMANBioGRID, DIP, HPRD18562274 22939629 24981860 26344197 34079125 9201987 details
RPB2_HUMANRPAB1_HUMANBioGRID, DIP, MINT22939629 24981860 26344197 27193682 9201987 details
RPB2_HUMANZSCA1_HUMANBioGRID, IntAct20211142 details
RPB2_HUMANLZTR1_HUMANBioGRID, IntAct20211142 details
RPB2_HUMANNEMO_HUMANBioGRID, IntAct20211142 details
RPB2_HUMANRPAB5_HUMANBioGRID, HPRD24981860 26344197 9201987 details
RPB2_HUMANRPAB3_HUMANBioGRID, HPRD17643375 24981860 26344197 9201987 details
RPB2_HUMANRPAB4_HUMANBioGRID24981860 26344197 9201987 details
RPB2_HUMANBTF3_HUMANBioGRID, HPRD2320128 details
RPB2_HUMANRPB1_HUMANBioGRID19240132 22939629 24981860 26344197 31048545 details
RPB2_HUMANTCP4_HUMANBioGRID10024883 details
RPB2_HUMANCALM1_HUMANBioGRID15840729 details
RPB2_HUMANCALM2_HUMANBioGRID15840729 details
RPB2_HUMANCALM3_HUMANBioGRID15840729 details
RPB2_HUMANCCNH_HUMANBioGRID9334327 details
RPB2_HUMANCDK7_HUMANBioGRID9334327 details
RPB2_HUMANITCH_HUMANBioGRID16055720 details
RPB2_HUMANNEDD4_HUMANBioGRID16055720 details
RPB2_HUMANOTUD5_HUMANBioGRID30508113 details
RPB2_HUMANPTEN_HUMANBioGRID31685992 details
RPB2_HUMANMYC_HUMANBioGRID, IntAct17314511 17353931 29467282 details
RPB2_HUMANGSK3B_HUMANIntAct17353931 details
RPB2_HUMANMAGI2_HUMANIntAct17353931 details
RPB2_HUMANRECQ5_HUMANBioGRID, DIP18562274 19270065 24981860 32900933 details
RPB2_HUMANESR1_HUMANBioGRID, IntAct16957778 31527615 details
RPB2_HUMANMED28_HUMANBioGRID15175163 20133760 24981860 details
RPB2_HUMANRPB11_HUMANBioGRID15282305 17643375 24981860 26344197 details
RPB2_HUMANAIRE_HUMANBioGRID20085707 details
RPB2_HUMANINT3_HUMANBioGRID20133760 details
RPB2_HUMANINT5_HUMANBioGRID20133760 details
RPB2_HUMANINT6_HUMANBioGRID20133760 details
RPB2_HUMANINT1_HUMANBioGRID20133760 details
RPB2_HUMANZC3HD_HUMANBioGRID20133760 details
RPB2_HUMANWDR82_HUMANBioGRID20516061 details
RPB2_HUMANSEM1_HUMANBioGRID16239144 details
RPB2_HUMANSEML_HUMANBioGRID16239144 details
RPB2_HUMANINT10_HUMANBioGRID16239144 details
RPB2_HUMANMEN1_HUMANBioGRID, HPRD14992727 details
RPB2_HUMANSRC_HUMANBioGRID16957778 details
RPB2_HUMANPSB9_HUMANBioGRID16957778 details
RPB2_HUMANELOA1_HUMANBioGRID16957778 details
RPB2_HUMANSPT5H_HUMANBioGRID26344197 26496610 29395067 details
RPB2_HUMANMCE1_HUMANBioGRID27432908 27880917 29395067 details
RPB2_HUMANDPOE1_HUMANBioGRID27235625 details
RPB2_HUMANPKCB1_HUMANBioGRID26655721 details
RPB2_HUMANSCAI_HUMANBioGRID28700933 details
RPB2_HUMANNCBP2_HUMANBioGRID29395067 details