Entity Details

Primary name MDHM_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP40926
EntryNameMDHM_HUMAN
FullNameMalate dehydrogenase, mitochondrial
TaxID9606
Evidenceevidence at protein level
Length338
SequenceStatuscomplete
DateCreated1995-02-01
DateModified2021-06-02

Ontological Relatives

GenesMDH2

GO terms

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GOName
GO:0003723 RNA binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0006094 gluconeogenesis
GO:0006099 tricarboxylic acid cycle
GO:0006107 oxaloacetate metabolic process
GO:0006108 malate metabolic process
GO:0006734 NADH metabolic process
GO:0009060 aerobic respiration
GO:0016020 membrane
GO:0030060 L-malate dehydrogenase activity
GO:0043621 protein self-association
GO:0046554 malate dehydrogenase (NADP+) activity
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR001236 Lactate/malate dehydrogenase, N-terminalDomainDomain
IPR001252 Malate dehydrogenase, active siteSiteActive site
IPR001557 L-lactate/malate dehydrogenaseFamilyFamily
IPR010097 Malate dehydrogenase, type 1FamilyFamily
IPR015955 Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminalFamilyHomologous superfamily
IPR022383 Lactate/malate dehydrogenase, C-terminalDomainDomain
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB04272 Citric acidDrugbanksmall molecule
DB09092 XanthinolDrugbanksmall molecule