Entity Details
| Primary name |
GCST_HUMAN |
| Entity type |
UniProt |
| Source |
Source Link |
Details
| Accession | P48728 |
| EntryName | GCST_HUMAN |
| FullName | Aminomethyltransferase, mitochondrial |
| TaxID | 9606 |
| Evidence | evidence at protein level |
| Length | 403 |
| SequenceStatus | complete |
| DateCreated | 1996-02-01 |
| DateModified | 2021-06-02 |
Subcellular Location
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| Subcellular Location |
| Mitochondrion |
Domains
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| Domain | Name | Category | Type |
| IPR006222 | Aminomethyltransferase, folate-binding domain | Domain | Domain |
| IPR006223 | Glycine cleavage system T protein | Family | Family |
| IPR013977 | Glycine cleavage T-protein, C-terminal barrel domain | Domain | Domain |
| IPR027266 | GTP-binding protein TrmE/Glycine cleavage system T protein, domain 1 | Family | Homologous superfamily |
| IPR028896 | Aminomethyltransferase-like | Family | Family |
| IPR029043 | Glycine cleavage T-protein/YgfZ, C-terminal | Family | Homologous superfamily |
Diseases
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| Disease ID | Source | Name | Description |
| 605899 | OMIM | Non-ketotic hyperglycinemia (NKH) | Autosomal recessive disease characterized by accumulation of a large amount of glycine in body fluid and by severe neurological symptoms. The disease is caused by variants affecting the gene represented in this entry. |
Drugs
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| Drug | Name | Source | Type |
| DB00116 | Tetrahydrofolic acid | Drugbank | small molecule |
| DB00145 | Glycine | Drugbank | small molecule |
| DB00157 | NADH | Drugbank | small molecule |
| DB04789 | 5-methyltetrahydrofolic acid | Drugbank | small molecule |
Interactions
3 interactions