Entity Details

Primary name SOS2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ07890
EntryNameSOS2_HUMAN
FullNameSon of sevenless homolog 2
TaxID9606
Evidenceevidence at protein level
Length1332
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesSOS2

GO terms

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GOName
GO:0001782 B cell homeostasis
GO:0003677 DNA binding
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005829 cytosol
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0033081 regulation of T cell differentiation in thymus
GO:0042129 regulation of T cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0046982 protein heterodimerization activity
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:2000973 regulation of pro-B cell differentiation

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000219 Dbl homology (DH) domainDomainDomain
IPR000651 Ras-like guanine nucleotide exchange factor, N-terminalDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR007125 Histone H2A/H2B/H3DomainDomain
IPR008937 Ras-like guanine nucleotide exchange factorFamilyFamily
IPR009072 Histone-foldFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR019804 Ras guanine-nucleotide exchange factor, conserved siteSiteConserved site
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR035899 Dbl homology (DH) domain superfamilyFamilyHomologous superfamily
IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

29 interactions

InteractorPartnerSourcesPublicationsLink
SOS2_HUMANGRB2_HUMANBioGRID, HPRD, IntAct, MINT10940929 14679214 17474147 19380743 20936779 21706016 21988832 28514442 31980649 32062451 32203420 7629138 details
SOS2_HUMANPLCG1_HUMANBioGRID, HPRD, IntAct10940929 17474147 details
SOS2_HUMANABL1_HUMANHPRD, IntAct14679214 17474147 details
SOS2_HUMANCRK_HUMANBioGRID, IntAct17474147 19380743 details
SOS2_HUMANSRC_HUMANIntAct17474147 details
SOS2_HUMANFYN_HUMANIntAct17474147 details
SOS2_HUMANNCK1_HUMANIntAct17474147 details
SOS2_HUMANP85A_HUMANIntAct17474147 details
SOS2_HUMANEGFR_HUMANBioGRID, HPRD, IntAct10675333 18271526 19531499 23956138 24658140 24797263 25402006 31959764 31980649 details
SOS2_HUMANLYOX_HUMANmatrixdb25118846 details
SOS2_HUMANGRAP2_HUMANBioGRID, HPRD10820259 details
SOS2_HUMANITSN2_HUMANBioGRID22558309 details
SOS2_HUMANBIN1_HUMANBioGRID9182529 details
SOS2_HUMANCBP_HUMANBioGRID32238831 details
SOS2_HUMANSH319_HUMANHPRD14551139 details
SOS2_HUMANPACN3_HUMANHPRD, IntAct14679214 details
SOS2_HUMANSNX9_HUMANHPRD, IntAct14679214 details
SOS2_HUMANCD2AP_HUMANHPRD, IntAct14679214 details
SOS2_HUMANSNX18_HUMANHPRD, IntAct14679214 details
SOS2_HUMANRXRB_HUMANIntAct20195357 details
SOS2_HUMANCLUS_HUMANIntAct31413325 details
SOS2_HUMANGRB7_HUMANIntAct29290818 details
SOS2_HUMANRASK_HUMANIntAct29290818 details
SOS2_HUMANSHC1_HUMANBioGRID, HPRD10675333 19380743 details
SOS2_HUMANESR1_HUMANBioGRID15173068 details
SOS2_HUMANLRRK1_HUMANBioGRID20697350 details
SOS2_HUMANRASH_HUMANHPRD12628188 details
SOS2_HUMANABI1_HUMANHPRD11003655 details
SOS2_HUMANCRKL_HUMANHPRD8943292 details