Entity Details

Primary name CNKR2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WXI2
EntryNameCNKR2_HUMAN
FullNameConnector enhancer of kinase suppressor of ras 2
TaxID9606
Evidenceevidence at protein level
Length1034
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesCNKSR2

GO terms

Show/Hide Table
GOName
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009966 regulation of signal transduction
GO:0019901 protein kinase binding
GO:0035556 intracellular signal transduction
GO:0042802 identical protein binding
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0070062 extracellular exosome
GO:0098978 glutamatergic synapse
GO:0099147 extrinsic component of postsynaptic density membrane
GO:0099173 postsynapse organization

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm
Membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001478 PDZ domainDomainDomain
IPR001660 Sterile alpha motif domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR010599 Connector enhancer of kinase suppressor of ras 2/3 domainDomainDomain
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR013761 Sterile alpha motif/pointed domain superfamilyFamilyHomologous superfamily
IPR017874 CRIC domainDomainDomain
IPR036034 PDZ superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
301008 OMIMMental retardation, X-linked, syndromic, Houge type (MRXSHG)A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXSHG is characterized by delayed development, intellectual disability, speech and language delay, and early-onset seizures. Carrier females may be mildly affected. The disease is caused by variants affecting the gene represented in this entry.