Entity Details

Primary name TOMT_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ8WZ04
EntryNameTOMT_HUMAN
FullNameTransmembrane O-methyltransferase
TaxID9606
Evidenceevidence at transcript level
Length291
SequenceStatuscomplete
DateCreated2008-11-25
DateModified2021-06-02

Ontological Relatives

GenesLRTOMT

GO terms

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GOName
GO:0005783 endoplasmic reticulum
GO:0005886 plasma membrane
GO:0007605 sensory perception of sound
GO:0008171 O-methyltransferase activity
GO:0016021 integral component of membrane
GO:0016206 catechol O-methyltransferase activity
GO:0032259 methylation
GO:0032502 developmental process
GO:0042135 neurotransmitter catabolic process
GO:0042417 dopamine metabolic process
GO:0042424 catecholamine catabolic process
GO:0060117 auditory receptor cell development
GO:0102084 L-dopa O-methyltransferase activity
GO:0102938 orcinol O-methyltransferase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Membrane

Domains

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DomainNameCategoryType
IPR002935 Class I-like SAM-dependent O-methyltransferaseFamilyFamily
IPR029063 S-adenosyl-L-methionine-dependent methyltransferaseFamilyHomologous superfamily
IPR033025 Transmembrane O-methyltransferaseFamilyFamily

Diseases

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Disease IDSourceNameDescription
611451 OMIMDeafness, autosomal recessive, 63 (DFNB63)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.

Interactions

0 interactions

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