Entity Details

Primary name GGH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ92820
EntryNameGGH_HUMAN
FullNameGamma-glutamyl hydrolase
TaxID9606
Evidenceevidence at protein level
Length318
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesGGH

GO terms

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GOName
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005773 vacuole
GO:0005829 cytosol
GO:0008238 exopeptidase activity
GO:0008242 omega peptidase activity
GO:0010043 response to zinc ion
GO:0032868 response to insulin
GO:0034722 gamma-glutamyl-peptidase activity
GO:0035578 azurophil granule lumen
GO:0035580 specific granule lumen
GO:0042470 melanosome
GO:0042493 response to drug
GO:0043312 neutrophil degranulation
GO:0045471 response to ethanol
GO:0046900 tetrahydrofolylpolyglutamate metabolic process
GO:0070062 extracellular exosome
GO:0070500 poly-gamma-glutamate metabolic process
GO:1904724 tertiary granule lumen

Subcellular Location

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Subcellular Location
Lysosome
Melanosome
Secreted

Domains

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DomainNameCategoryType
IPR011697 Peptidase C26FamilyFamily
IPR015527 Peptidase C26, gamma-glutamyl hydrolaseFamilyFamily
IPR029062 Class I glutamine amidotransferase-likeFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00158 Folic acidDrugbanksmall molecule
DB00563 MethotrexateDrugbanksmall molecule

Interactions

4 interactions

InteractorPartnerSourcesPublicationsLink
GGH_HUMANSGTB_HUMANBioGRID, IntAct32296183 details
GGH_HUMANDNLI4_HUMANBioGRID22990118 details
GGH_HUMANGGH_HUMANBioGRID, HPRD11953431 details
GGH_HUMANVATB1_HUMANBioGRID21674799 details