Entity Details

Primary name METH_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ99707
EntryNameMETH_HUMAN
FullNameMethionine synthase
TaxID9606
Evidenceevidence at protein level
Length1265
SequenceStatuscomplete
DateCreated1997-11-01
DateModified2021-06-02

Ontological Relatives

GenesMTR

GO terms

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GOName
GO:0000096 sulfur amino acid metabolic process
GO:0005829 cytosol
GO:0007399 nervous system development
GO:0008270 zinc ion binding
GO:0008705 methionine synthase activity
GO:0009086 methionine biosynthetic process
GO:0009235 cobalamin metabolic process
GO:0031103 axon regeneration
GO:0031419 cobalamin binding
GO:0032259 methylation
GO:0042558 pteridine-containing compound metabolic process
GO:0048678 response to axon injury
GO:0071732 cellular response to nitric oxide

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000489 Pterin-binding domainDomainDomain
IPR003726 Homocysteine-binding domainDomainDomain
IPR003759 Cobalamin (vitamin B12)-binding module, cap domainDomainDomain
IPR004223 Vitamin B12-dependent methionine synthase, activation domainDomainDomain
IPR006158 Cobalamin (vitamin B12)-binding domainDomainDomain
IPR011005 Dihydropteroate synthase-likeFamilyHomologous superfamily
IPR011822 Cobalamin-dependent methionine synthaseFamilyFamily
IPR033706 Methionine synthase, B12-binding domainDomainDomain
IPR036589 Homocysteine-binding domain superfamilyFamilyHomologous superfamily
IPR036594 Methionine synthase domainFamilyHomologous superfamily
IPR036724 Cobalamin-binding domain superfamilyFamilyHomologous superfamily
IPR037010 Vitamin B12-dependent methionine synthase, activation domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00115 CyanocobalaminDrugbanksmall molecule
DB00116 Tetrahydrofolic acidDrugbanksmall molecule
DB00134 MethionineDrugbanksmall molecule
DB00200 HydroxocobalaminDrugbanksmall molecule
DB03614 MecobalaminDrugbanksmall molecule
DB11256 Levomefolic acidSwissprotsmall molecule
DB11590 ThimerosalDrugbanksmall molecule