Entity Details

Primary name PLPL8_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9NP80
EntryNamePLPL8_HUMAN
FullNameCalcium-independent phospholipase A2-gamma
TaxID9606
Evidenceevidence at protein level
Length782
SequenceStatuscomplete
DateCreated2007-09-11
DateModified2021-06-02

Ontological Relatives

GenesPNPLA8

GO terms

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GOName
GO:0001516 prostaglandin biosynthetic process
GO:0004620 phospholipase activity
GO:0004622 lysophospholipase activity
GO:0005524 ATP binding
GO:0005739 mitochondrion
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005789 endoplasmic reticulum membrane
GO:0006631 fatty acid metabolic process
GO:0008219 cell death
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019369 arachidonic acid metabolic process
GO:0031966 mitochondrial membrane
GO:0034638 phosphatidylcholine catabolic process
GO:0036151 phosphatidylcholine acyl-chain remodeling
GO:0036152 phosphatidylethanolamine acyl-chain remodeling
GO:0043651 linoleic acid metabolic process
GO:0046338 phosphatidylethanolamine catabolic process
GO:0047499 calcium-independent phospholipase A2 activity
GO:0050482 arachidonic acid secretion
GO:0055088 lipid homeostasis
GO:0070328 triglyceride homeostasis
GO:0102545 phosphatidyl phospholipase B activity

Subcellular Location

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Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane
Mitochondrion membrane
Peroxisome membrane

Domains

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DomainNameCategoryType
IPR002641 Patatin-like phospholipase domainDomainDomain
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipaseFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
251950 OMIMMitochondrial myopathy with lactic acidosis (MMLA)An autosomal recessive disorder characterized by progressive muscle weakness, hypotonia, seizures, poor weight gain, lactic acidosis, and elevated serum pyruvate concentration. Some patients manifest growth failure and moderate neural deafness. The disease is caused by variants affecting the gene represented in this entry.

Interactions

0 interactions

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