Entity Details

Primary name CP8B1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ9UNU6
EntryNameCP8B1_HUMAN
FullName7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase
TaxID9606
Evidenceevidence at protein level
Length501
SequenceStatuscomplete
DateCreated2001-02-21
DateModified2021-06-02

Ontological Relatives

GenesCYP8B1

GO terms

Show/Hide Table
GOName
GO:0005506 iron ion binding
GO:0005789 endoplasmic reticulum membrane
GO:0006699 bile acid biosynthetic process
GO:0008397 sterol 12-alpha-hydroxylase activity
GO:0016021 integral component of membrane
GO:0016125 sterol metabolic process
GO:0019825 oxygen binding
GO:0020037 heme binding
GO:0031667 response to nutrient levels
GO:0033779 5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase activity
GO:0038183 bile acid signaling pathway
GO:0045797 positive regulation of intestinal cholesterol absorption
GO:0070723 response to cholesterol

Subcellular Location

Show/Hide Table
Subcellular Location
Endoplasmic reticulum membrane
Microsome membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR001128 Cytochrome P450FamilyFamily
IPR002403 Cytochrome P450, E-class, group IVFamilyFamily
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-typeFamilyFamily
IPR030686 Cytochrome P450 8B1FamilyFamily
IPR036396 Cytochrome P450 superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink