Entity Details

Primary name HPGDS_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO60760
EntryNameHPGDS_HUMAN
FullNameHematopoietic prostaglandin D synthase
TaxID9606
Evidenceevidence at protein level
Length199
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesHPGDS

GO terms

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GOName
GO:0000287 magnesium ion binding
GO:0004364 glutathione transferase activity
GO:0004667 prostaglandin-D synthase activity
GO:0005509 calcium ion binding
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006693 prostaglandin metabolic process
GO:0006749 glutathione metabolic process
GO:0007165 signal transduction
GO:0007626 locomotory behavior
GO:0019371 cyclooxygenase pathway
GO:0042803 protein homodimerization activity
GO:0043231 intracellular membrane-bounded organelle
GO:1901687 glutathione derivative biosynthetic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR004045 Glutathione S-transferase, N-terminalDomainDomain
IPR004046 Glutathione S-transferase, C-terminalDomainDomain
IPR010987 Glutathione S-transferase, C-terminal-likeDomainDomain
IPR036249 Thioredoxin-like superfamilyFamilyHomologous superfamily
IPR036282 Glutathione S-transferase, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00143 GlutathioneDrugbanksmall molecule
DB00755 TretinoinDrugbanksmall molecule
DB01897 2-(2f-Benzothiazolyl)-5-Styryl-3-(4f-Phthalhydrazidyl)Tetrazolium ChlorideDrugbanksmall molecule
DB03310 Glutathione disulfideDrugbanksmall molecule
DB07613 3-phenyl-5-(1H-pyrazol-3-yl)isoxazoleDrugbanksmall molecule
DB07614 PHENYL-5-(1H-PYRAZOL-3-YL)-1,3-THIAZOLEDrugbanksmall molecule
DB07615 TranilastDrugbanksmall molecule
DB07616 4-{[4-(4-fluoro-3-methylphenyl)-1,3-thiazol-2-yl]amino}-2-hydroxybenzoic acidDrugbanksmall molecule
DB07917 4-(BENZHYDRYLOXY)-1-[3-(1H-TETRAAZOL-5-YL)PROPYL]PIPERIDINEDrugbanksmall molecule
DB08313 NocodazoleDrugbanksmall molecule
DB08695 3-(4-nitrophenyl)-1H-pyrazoleDrugbanksmall molecule
DB08790 1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACIDDrugbanksmall molecule