Entity Details

Primary name AL1L1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO75891
EntryNameAL1L1_HUMAN
FullNameCytosolic 10-formyltetrahydrofolate dehydrogenase
TaxID9606
Evidenceevidence at protein level
Length902
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesALDH1L1

GO terms

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GOName
GO:0003824 catalytic activity
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0005829 cytosol
GO:0006730 one-carbon metabolic process
GO:0009058 biosynthetic process
GO:0009258 10-formyltetrahydrofolate catabolic process
GO:0016155 formyltetrahydrofolate dehydrogenase activity
GO:0016742 hydroxymethyl-, formyl- and related transferase activity
GO:0046655 folic acid metabolic process
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001555 Phosphoribosylglycinamide formyltransferase, active siteSiteActive site
IPR002376 Formyl transferase, N-terminalDomainDomain
IPR005793 Formyl transferase, C-terminalDomainDomain
IPR009081 Phosphopantetheine binding ACP domainDomainDomain
IPR011034 Formyl transferase-like, C-terminal domain superfamilyFamilyHomologous superfamily
IPR011407 10-formyltetrahydrofolate dehydrogenaseFamilyFamily
IPR015590 Aldehyde dehydrogenase domainDomainDomain
IPR016160 Aldehyde dehydrogenase, cysteine active siteSiteConserved site
IPR016161 Aldehyde/histidinol dehydrogenaseFamilyHomologous superfamily
IPR016162 Aldehyde dehydrogenase, N-terminalFamilyHomologous superfamily
IPR016163 Aldehyde dehydrogenase, C-terminalFamilyHomologous superfamily
IPR029510 Aldehyde dehydrogenase, glutamic acid active siteSiteConserved site
IPR036477 Formyl transferase, N-terminal domain superfamilyFamilyHomologous superfamily
IPR036736 ACP-like superfamilyFamilyHomologous superfamily
IPR037022 Formyl transferase, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00116 Tetrahydrofolic acidDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
AL1L1_HUMANAPBP2_HUMANBioGRID, IntAct32296183 details
AL1L1_HUMANCHIP_HUMANBioGRID29979702 details