Entity Details

Primary name CCN6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionO95389
EntryNameCCN6_HUMAN
FullNameCellular communication network factor 6
TaxID9606
Evidenceevidence at transcript level
Length354
SequenceStatuscomplete
DateCreated2003-08-15
DateModified2021-06-02

Ontological Relatives

GenesCCN6

GO terms

Show/Hide Table
GOName
GO:0005178 integrin binding
GO:0005520 insulin-like growth factor binding
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0008083 growth factor activity
GO:0008201 heparin binding
GO:0008285 negative regulation of cell population proliferation
GO:0016525 negative regulation of angiogenesis
GO:0031012 extracellular matrix
GO:0051881 regulation of mitochondrial membrane potential
GO:0060548 negative regulation of cell death
GO:1903426 regulation of reactive oxygen species biosynthetic process

Subcellular Location

Show/Hide Table
Subcellular Location
Mitochondrion
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000867 Insulin-like growth factor-binding protein, IGFBPDomainDomain
IPR000884 Thrombospondin type-1 (TSP1) repeatRepeatRepeat
IPR006207 Cystine knot, C-terminalDomainDomain
IPR006208 Glycoprotein hormone subunit betaDomainDomain
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR012395 IGFBP-related, CNNFamilyFamily
IPR017891 Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved siteSiteConserved site
IPR036383 Thrombospondin type-1 (TSP1) repeat superfamilyFamilyHomologous superfamily
IPR043973 CCN, TSP1 domainDomainDomain

Diseases

Show/Hide Table
Disease IDSourceNameDescription
208230 OMIMProgressive pseudorheumatoid arthropathy of childhood (PPAC)Autosomal recessive disorder characterized by stiffness and swelling of joints, motor weakness and joint contractures. Signs and symptoms of the disease develop typically between three and eight years of age. This progressive disease is a primary disorder of articular cartilage with continued cartilage loss and destructive bone changes with aging. The disease is caused by variants affecting the gene represented in this entry.

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink