Entity Details

Primary name UROK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP00749
EntryNameUROK_HUMAN
FullNameUrokinase-type plasminogen activator
TaxID9606
Evidenceevidence at protein level
Length431
SequenceStatuscomplete
DateCreated1986-07-21
DateModified2021-06-02

Ontological Relatives

GenesPLAU

GO terms

Show/Hide Table
GOName
GO:0001666 response to hypoxia
GO:0004252 serine-type endopeptidase activity
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0006508 proteolysis
GO:0006935 chemotaxis
GO:0007165 signal transduction
GO:0007596 blood coagulation
GO:0009986 cell surface
GO:0010469 regulation of signaling receptor activity
GO:0014909 smooth muscle cell migration
GO:0014910 regulation of smooth muscle cell migration
GO:0030335 positive regulation of cell migration
GO:0031639 plasminogen activation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0035579 specific granule membrane
GO:0042127 regulation of cell population proliferation
GO:0042730 fibrinolysis
GO:0043312 neutrophil degranulation
GO:0061041 regulation of wound healing
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:2000097 regulation of smooth muscle cell-matrix adhesion

Subcellular Location

Show/Hide Table
Subcellular Location
Secreted

Domains

Show/Hide Table
DomainNameCategoryType
IPR000001 KringleDomainDomain
IPR000742 EGF-like domainDomainDomain
IPR001254 Serine proteases, trypsin domainDomainDomain
IPR001314 Peptidase S1A, chymotrypsin familyFamilyFamily
IPR009003 Peptidase S1, PA clanFamilyHomologous superfamily
IPR013806 Kringle-like foldFamilyHomologous superfamily
IPR018056 Kringle, conserved siteSiteConserved site
IPR018114 Serine proteases, trypsin family, histidine active siteSiteActive site
IPR033116 Serine proteases, trypsin family, serine active siteSiteActive site
IPR034814 Urokinase-type plasminogen activatorFamilyFamily
IPR038178 Kringle superfamilyFamilyHomologous superfamily
IPR043504 Peptidase S1, PA clan, chymotrypsin-like foldFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
601709 OMIMQuebec platelet disorder (QPD)An autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins. The disease is caused by variants affecting the gene represented in this entry.

Drugs

Show/Hide Table
DrugNameSourceType
DB00594 AmilorideDrugbanksmall molecule
DB01725 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamideDrugbanksmall molecule
DB01905 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-CarboxamidineDrugbanksmall molecule
DB01977 6-(N-Phenylcarbamyl)-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB02287 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidineDrugbanksmall molecule
DB02398 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB02473 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB02526 CRA_10655Drugbanksmall molecule
DB02551 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB02705 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-NaphthalenecarboxamidineDrugbanksmall molecule
DB03046 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-CarboximidamideDrugbanksmall molecule
DB03082 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-NaphthamideDrugbanksmall molecule
DB03127 BenzamidineDrugbanksmall molecule
DB03136 4-Iodobenzo[B]Thiophene-2-CarboxamidineDrugbanksmall molecule
DB03159 CRA_8696Drugbanksmall molecule
DB03476 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-CarboxamidineDrugbanksmall molecule
DB03729 2-Amino-1H-benzimidazol-5-olDrugbanksmall molecule
DB03782 N-(1-adamantyl)-N'-(4-guanidinobenzyl)ureaDrugbanksmall molecule
DB03865 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-CarboxamidineDrugbanksmall molecule
DB03876 Thieno[2,3-B]Pyridine-2-CarboxamidineDrugbanksmall molecule
DB04059 8-(Pyrimidin-2-Ylamino)Naphthalene-2-CarboximidamideDrugbanksmall molecule
DB04172 [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-AlanineDrugbanksmall molecule
DB05254 FibrinolysinDrugbankbiotech
DB06855 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidineDrugbanksmall molecule
DB06856 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINEDrugbanksmall molecule
DB06857 N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDEDrugbanksmall molecule
DB07076 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDEDrugbanksmall molecule
DB07122 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidineDrugbanksmall molecule
DB07129 (2R)-1-(2,6-dimethylphenoxy)propan-2-amineDrugbanksmall molecule
DB07625 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamideDrugbanksmall molecule
DB07626 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamideDrugbanksmall molecule
DB08072 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDEDrugbanksmall molecule
DB08697 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamideDrugbanksmall molecule

Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
UROK_HUMANHEM1_HUMANBioGRID, IntAct21988832 details
UROK_HUMANBTK_HUMANBioGRID, IntAct21988832 details
UROK_HUMANMYC_HUMANBioGRID, IntAct21988832 details
UROK_HUMANPAI1_HUMANBioGRID, HPRD, MINT2161846 22449964 2544876 3090045 9184208 details
UROK_HUMANADA28_HUMANBioGRID, IntAct32296183 details
UROK_HUMANUPAR_HUMANBioGRID, DIP, HPRD, IntAct11501527 16879932 18376415 19017363 24457100 3023326 3031025 details
UROK_HUMANSLUR1_HUMANUniProt25168896 details
UROK_HUMANGDN_HUMANBioGRID, IntAct26186194 28514442 9184208 details
UROK_HUMANA4_HUMANIntAct32814053 details
UROK_HUMANTPA_HUMANBioGRID, HPRD7721771 details
UROK_HUMANIPSP_HUMANBioGRID, HPRD2551064 2752144 9365930 details
UROK_HUMANLRP2_HUMANBioGRID, HPRD8344937 details
UROK_HUMANPAI2_HUMANBioGRID, HPRD2161846 2166055 8388810 details
UROK_HUMANPDGFC_HUMANBioGRID22035541 details
UROK_HUMANSCAM5_HUMANBioGRID21163940 details
UROK_HUMANCEBPG_HUMANBioGRID23661758 details
UROK_HUMANKAT8_HUMANBioGRID24953651 details
UROK_HUMANTX101_HUMANBioGRID19017363 details
UROK_HUMANSPB6_HUMANHPRD7548163 details
UROK_HUMANPLMN_HUMANHPRD2829380 3920216 4226004 details
UROK_HUMANTHRB_HUMANHPRD10996659 8428004 details
UROK_HUMANST14_HUMANHPRD10962009 details
UROK_HUMANCATB_HUMANHPRD1900515 details
UROK_HUMANCATL1_HUMANHPRD1551416 details
UROK_HUMANA2AP_HUMANHPRD134998 details
UROK_HUMANHGF_HUMANHPRD1334458 details
UROK_HUMANNID1_HUMANHPRD1499567 details
UROK_HUMANMPRI_HUMANHPRD9566979 details