Entity Details

Primary name MATK_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP42679
EntryNameMATK_HUMAN
FullNameMegakaryocyte-associated tyrosine-protein kinase
TaxID9606
Evidenceevidence at protein level
Length507
SequenceStatuscomplete
DateCreated1995-11-01
DateModified2021-06-02

Ontological Relatives

GenesMATK

GO terms

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GOName
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0005829 cytosol
GO:0006468 protein phosphorylation
GO:0008284 positive regulation of cell population proliferation
GO:0016020 membrane
GO:0038128 ERBB2 signaling pathway

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001452 SH3 domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR035027 CSK-like, SH2 domainDomainDomain
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
MATK_HUMANEWS_HUMANBioGRID, HPRD, IntAct16189514 details
MATK_HUMANERBB2_HUMANBioGRID, HPRD, MINT12122014 16273093 9461599 details
MATK_HUMANCAC1A_HUMANBioGRID, IntAct21078624 details
MATK_HUMANLRRK2_HUMANBioGRID, IntAct24510904 24947832 details
MATK_HUMANANDR_HUMANBioGRID, IntAct24728074 details
MATK_HUMANMET_HUMANBioGRID, IntAct24728074 details
MATK_HUMANFRS3_HUMANBioGRID, IntAct25814554 details
MATK_HUMANLRRK1_HUMANBioGRID, IntAct24947832 29513927 details
MATK_HUMANKLK6_HUMANIntAct32814053 details
MATK_HUMANBACE2_HUMANIntAct32814053 details
MATK_HUMANNTRK1_HUMANBioGRID, HPRD10329710 details
MATK_HUMANKIT_HUMANBioGRID, HPRD7536744 9038210 details
MATK_HUMANSRC_HUMANBioGRID, HPRD7530249 details
MATK_HUMANSMUF1_HUMANBioGRID20804422 details
MATK_HUMANPTPRD_HUMANBioGRID22305495 details
MATK_HUMANSHPS1_HUMANBioGRID17999719 19299420 21799000 details
MATK_HUMANBIP_HUMANBioGRID19299420 details
MATK_HUMANGRP75_HUMANBioGRID19299420 details
MATK_HUMANAKT1_HUMANBioGRID19299420 details
MATK_HUMANILK_HUMANBioGRID19299420 details
MATK_HUMANMATK_HUMANBioGRID19299420 details
MATK_HUMANERBB3_HUMANBioGRID22973453 details
MATK_HUMANERBB4_HUMANBioGRID22973453 details
MATK_HUMANFAK2_HUMANHPRD, MINT12063569 details
MATK_HUMANHS90B_HUMANIntAct22939624 details
MATK_HUMANCDC37_HUMANIntAct25036637 details
MATK_HUMANCD36_HUMANBioGRID, HPRD9171348 details
MATK_HUMANPAXI_HUMANBioGRID, HPRD10080957 details
MATK_HUMANHS90A_HUMANBioGRID22939624 details
MATK_HUMANBRCA1_HUMANBioGRID23901102 details
MATK_HUMANEGFR_HUMANBioGRID9461599 details
MATK_HUMANIGF1R_HUMANBioGRID21799000 details
MATK_HUMANLYN_HUMANHPRD1722201 9171348 details