Entity Details

Primary name KCNQ4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP56696
EntryNameKCNQ4_HUMAN
FullNamePotassium voltage-gated channel subfamily KQT member 4
TaxID9606
Evidenceevidence at protein level
Length695
SequenceStatuscomplete
DateCreated1999-07-15
DateModified2021-06-02

Ontological Relatives

GenesKCNQ4

GO terms

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GOName
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005267 potassium channel activity
GO:0005516 calmodulin binding
GO:0005886 plasma membrane
GO:0006813 potassium ion transport
GO:0007605 sensory perception of sound
GO:0008076 voltage-gated potassium channel complex
GO:0009925 basal plasma membrane
GO:0016021 integral component of membrane
GO:0034765 regulation of ion transmembrane transport
GO:0042472 inner ear morphogenesis
GO:0071805 potassium ion transmembrane transport

Subcellular Location

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Subcellular Location
Basal cell membrane

Domains

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DomainNameCategoryType
IPR003937 Potassium channel, voltage dependent, KCNQFamilyFamily
IPR005821 Ion transport domainDomainDomain
IPR013821 Potassium channel, voltage dependent, KCNQ, C-terminalDomainDomain
IPR015573 Potassium channel, voltage dependent, KCNQ4FamilyFamily
IPR028325 Voltage-gated potassium channelFamilyFamily

Diseases

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Disease IDSourceNameDescription
600101 OMIMDeafness, autosomal dominant, 2A (DFNA2A)A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00228 EnfluraneDrugbanksmall molecule
DB01069 PromethazineDrugbanksmall molecule
DB01110 MiconazoleDrugbanksmall molecule
DB04953 EzogabineDrugbanksmall molecule
DB06089 ICA-105665Drugbanksmall molecule