Entity Details

Primary name CXCR4_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP61073
EntryNameCXCR4_HUMAN
FullNameC-X-C chemokine receptor type 4
TaxID9606
Evidenceevidence at protein level
Length352
SequenceStatuscomplete
DateCreated2004-04-26
DateModified2021-06-02

Ontological Relatives

GenesCXCR4

GO terms

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GOName
GO:0000187 obsolete activation of MAPK activity
GO:0001618 virus receptor activity
GO:0001666 response to hypoxia
GO:0001764 neuron migration
GO:0002064 epithelial cell development
GO:0002407 dendritic cell chemotaxis
GO:0003779 actin binding
GO:0004930 G protein-coupled receptor activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0006955 immune response
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007411 axon guidance
GO:0007420 brain development
GO:0008038 neuron recognition
GO:0009615 response to virus
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0014823 response to activity
GO:0015026 coreceptor activity
GO:0016021 integral component of membrane
GO:0016493 C-C chemokine receptor activity
GO:0016494 C-X-C chemokine receptor activity
GO:0019064 fusion of virus membrane with host plasma membrane
GO:0019722 calcium-mediated signaling
GO:0019957 C-C chemokine binding
GO:0022008 neurogenesis
GO:0022029 telencephalon cell migration
GO:0030054 cell junction
GO:0030155 regulation of cell adhesion
GO:0031252 cell leading edge
GO:0031410 cytoplasmic vesicle
GO:0031625 ubiquitin protein ligase binding
GO:0032027 myosin light chain binding
GO:0032991 protein-containing complex
GO:0035470 positive regulation of vascular wound healing
GO:0035690 cellular response to drug
GO:0038147 C-X-C motif chemokine 12 receptor activity
GO:0038160 CXCL12-activated CXCR4 signaling pathway
GO:0043067 regulation of programmed cell death
GO:0043130 ubiquitin binding
GO:0043217 myelin maintenance
GO:0043278 response to morphine
GO:0044409 entry into host
GO:0045446 endothelial cell differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
GO:0050792 regulation of viral process
GO:0050920 regulation of chemotaxis
GO:0050921 positive regulation of chemotaxis
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051924 regulation of calcium ion transport
GO:0060048 cardiac muscle contraction
GO:0060326 cell chemotaxis
GO:0061154 endothelial tube morphogenesis
GO:0070062 extracellular exosome
GO:0071345 cellular response to cytokine stimulus
GO:0120162 positive regulation of cold-induced thermogenesis
GO:1903861 positive regulation of dendrite extension
GO:1905322 positive regulation of mesenchymal stem cell migration
GO:1990478 response to ultrasound
GO:2000448 positive regulation of macrophage migration inhibitory factor signaling pathway

Subcellular Location

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Subcellular Location
Cell junction
Cell membrane
Early endosome
Late endosome
Lysosome

Domains

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DomainNameCategoryType
IPR000276 G protein-coupled receptor, rhodopsin-likeFamilyFamily
IPR000355 Chemokine receptor familyFamilyFamily
IPR001277 CXC chemokine receptor 4/atypical chemokine receptor 2FamilyFamily
IPR017452 GPCR, rhodopsin-like, 7TMDomainDomain
IPR022726 CXC chemokine receptor 4 N-terminal domainDomainDomain

Diseases

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Disease IDSourceNameDescription
193670 OMIMWHIM syndrome (WHIMS)Immunodeficiency disease characterized by neutropenia, hypogammaglobulinemia and extensive human papillomavirus (HPV) infection. Despite the peripheral neutropenia, bone marrow aspirates from affected individuals contain abundant mature myeloid cells, a condition termed myelokathexis. The disease is caused by variants affecting the gene represented in this entry.

Drugs

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DrugNameSourceType
DB00452 FramycetinDrugbanksmall molecule
DB05501 AMD-070Drugbanksmall molecule
DB06809 PlerixaforDrugbanksmall molecule
DB12698 IbalizumabDrugbankbiotech

Interactions

60 interactions

InteractorPartnerSourcesPublicationsLink
CXCR4_HUMANTLR2_HUMANDIP, I2D18765807 20802527 details
CXCR4_HUMANCCR5_HUMANBioGRID, DIP, HPRD, IntAct12429730 15660419 18632580 details
CXCR4_HUMANAT132_HUMANBioGRID, IntAct22645275 details
CXCR4_HUMANMYBB_HUMANBioGRID, IntAct21988832 details
CXCR4_HUMANACKR3_HUMANIntAct19380869 21730065 25775528 27331810 28862946 29386406 details
CXCR4_HUMANCXCR4_HUMANHPRD, IntAct10506573 12433920 19380869 23170857 details
CXCR4_HUMANGNAI1_HUMANHPRD, IntAct10506573 19380869 details
CXCR4_HUMANCXCR3_HUMANIntAct23170857 details
CXCR4_HUMANITCH_HUMANBioGRID19116316 22275353 24489825 28264927 details
CXCR4_HUMANB2MG_HUMANBioGRID18083706 details
CXCR4_HUMANUBP14_HUMANBioGRID19106094 details
CXCR4_HUMANR113A_HUMANBioGRID28978524 details
CXCR4_HUMANMUC24_HUMANMolecular Connections24094005 details
CXCR4_HUMANHG2A_HUMANMINT19665027 details
CXCR4_HUMANMYH9_HUMANHPRD, IntAct12421915 details
CXCR4_HUMANCXL14_HUMANMINT23669361 details
CXCR4_HUMANGNA13_HUMANBioGRID, HPRD, Molecular Connections11994484 23773523 details
CXCR4_HUMANCXCR5_HUMANBioGRID, Molecular Connections23773523 details
CXCR4_HUMANPECA1_HUMANIntAct24497640 details
CXCR4_HUMANCD4_HUMANBioGRID, HPRD, UniProt10816381 14592831 15660419 details
CXCR4_HUMANDREB_HUMANIntAct20215400 23926103 details
CXCR4_HUMANADA1D_HUMANIntAct28862946 29426850 details
CXCR4_HUMANADA1B_HUMANIntAct25775528 28862946 29426850 details
CXCR4_HUMANADA1A_HUMANIntAct25775528 27331810 28862946 details
CXCR4_HUMANEAA3_HUMANBioGRID, IntAct27173435 unassigned1312 details
CXCR4_HUMANARBK2_HUMANBioGRID, HPRD11668182 details
CXCR4_HUMANSTAM1_HUMANBioGRID20505072 22275353 details
CXCR4_HUMANPTPRC_HUMANHPRD, MINT12519755 21912642 details
CXCR4_HUMANV1AR_HUMANIntAct29386406 details
CXCR4_HUMANCAV1_HUMANBioGRID22275353 details
CXCR4_HUMANSDF1_HUMANBioGRID, HPRD10233851 21757744 25495026 8752281 details
CXCR4_HUMANJAK2_HUMANBioGRID, HPRD10506573 details
CXCR4_HUMANPTN11_HUMANBioGRID, HPRD11157475 details
CXCR4_HUMANJAK3_HUMANBioGRID, HPRD10506573 details
CXCR4_HUMANFAK1_HUMANBioGRID11668182 details
CXCR4_HUMANMTSS1_HUMANBioGRID28264927 details
CXCR4_HUMANSOCS1_HUMANBioGRID, HPRD12163560 29991678 details
CXCR4_HUMANSOCS3_HUMANBioGRID, HPRD12163560 details
CXCR4_HUMANHMGB1_HUMANBioGRID25495026 details
CXCR4_HUMANPTN6_HUMANBioGRID, HPRD10506573 details
CXCR4_HUMANSTAT1_HUMANHPRD10506573 details
CXCR4_HUMANARRB2_HUMANHPRD10644702 details
CXCR4_HUMANF10A1_HUMANBioGRID11751889 details
CXCR4_HUMANHIF1A_HUMANBioGRID17083723 details
CXCR4_HUMANCATG_HUMANHPRD12531874 details
CXCR4_HUMANPDIA1_HUMANBioGRID14592831 details
CXCR4_HUMANIQGA1_HUMANBioGRID30948266 details
CXCR4_HUMANUBC_HUMANBioGRID30195032 details
CXCR4_HUMANRALA_HUMANBioGRID30948266 details
CXCR4_HUMANHLAB_HUMANBioGRID18083706 details
CXCR4_HUMANSTAT2_HUMANHPRD10506573 details
CXCR4_HUMANBIRC3_HUMANBioGRID30948266 details
CXCR4_HUMANHSP7C_HUMANHPRD16365278 details
CXCR4_HUMANSDC4_HUMANHPRD15819887 details
CXCR4_HUMANELNE_HUMANHPRD12531874 details
CXCR4_HUMANJAK1_HUMANHPRD12163560 details
CXCR4_HUMANSTAT3_HUMANHPRD10506573 details
CXCR4_HUMANSTA5B_HUMANHPRD10506573 details
CXCR4_HUMANDPP4_HUMANHPRD11278278 details
CXCR4_HUMANVAV_HUMANHPRD15618472 details