Entity Details

Primary name PLCB2_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ00722
EntryNamePLCB2_HUMAN
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
TaxID9606
Evidenceevidence at protein level
Length1185
SequenceStatuscomplete
DateCreated1993-07-01
DateModified2021-06-02

Ontological Relatives

GenesPLCB2

GO terms

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GOName
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0005509 calcium ion binding
GO:0005829 cytosol
GO:0006644 phospholipid metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007223 Wnt signaling pathway, calcium modulating pathway
GO:0016042 lipid catabolic process
GO:0043647 inositol phosphate metabolic process
GO:0046488 phosphatidylinositol metabolic process
GO:0048015 phosphatidylinositol-mediated signaling
GO:0050913 sensory perception of bitter taste

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR014815 Phospholipase C-beta, C-terminal domainDomainDomain
IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domainDomainDomain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase betaFamilyFamily
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR028403 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2FamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR037862 PLC-beta, PH domainDomainDomain
IPR042531 Phospholipase C-beta, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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