Entity Details

Primary name RON_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ04912
EntryNameRON_HUMAN
FullNameMacrophage-stimulating protein receptor
TaxID9606
Evidenceevidence at protein level
Length1400
SequenceStatuscomplete
DateCreated1994-10-01
DateModified2021-06-02

Ontological Relatives

GenesMST1R

GO terms

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GOName
GO:0001725 stress fiber
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005011 macrophage colony-stimulating factor receptor activity
GO:0005524 ATP binding
GO:0005773 vacuole
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0006909 phagocytosis
GO:0006952 defense response
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275 multicellular organism development
GO:0007338 single fertilization
GO:0007399 nervous system development
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0009925 basal plasma membrane
GO:0009986 cell surface
GO:0016477 cell migration
GO:0019899 enzyme binding
GO:0033674 positive regulation of kinase activity
GO:0043235 receptor complex
GO:0043406 positive regulation of MAP kinase activity
GO:0045087 innate immune response
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0051897 positive regulation of protein kinase B signaling

Subcellular Location

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Subcellular Location
Membrane

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domainDomainDomain
IPR001627 Sema domainDomainDomain
IPR002909 IPT domainDomainDomain
IPR008266 Tyrosine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR016201 PSI domainDomainDomain
IPR016244 Tyrosine-protein kinase, HGF/MSP receptorFamilyFamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR020635 Tyrosine-protein kinase, catalytic domainDomainDomain
IPR036352 Sema domain superfamilyFamilyHomologous superfamily
IPR039413 RON, Sema domainDomainDomain

Diseases

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Drugs

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DrugNameSourceType
DB12010 FostamatinibDrugbanksmall molecule

Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
RON_HUMANCBL_HUMANBioGRID, MINT12802274 16740632 18273061 details
RON_HUMAN1433T_HUMANBioGRID, HPRD, MINT12919677 14505491 details
RON_HUMAN1433Z_HUMANBioGRID, HPRD, MINT12919677 14505491 details
RON_HUMANFURIN_HUMANMolecular Connections21114864 details
RON_HUMANHGFL_HUMANHPRD, IntAct22087277 25193665 9045873 details
RON_HUMANGRB2_HUMANBioGRID, HPRD16103119 7488076 8918464 details
RON_HUMANCHIP_HUMANBioGRID16740632 details
RON_HUMANGAB1_HUMANBioGRID, HPRD14982882 details
RON_HUMANAKT1_HUMANBioGRID, HPRD12919677 14505491 details
RON_HUMANPP1A_HUMANBioGRID14505491 details
RON_HUMAN1433B_HUMANBioGRID, HPRD12919677 14505491 details
RON_HUMAN1433E_HUMANBioGRID, HPRD12919677 14505491 details
RON_HUMAN1433F_HUMANBioGRID, HPRD12919677 14505491 details
RON_HUMAN1433S_HUMANBioGRID, HPRD12919677 14505491 details
RON_HUMANPTPRR_HUMANBioGRID28065597 details
RON_HUMANERBB2_HUMANBioGRID30898150 details
RON_HUMANCXB1_HUMANBioGRID30401746 details
RON_HUMANPLXB1_HUMANIntAct15184888 details
RON_HUMANPLXB2_HUMANIntAct15184888 details
RON_HUMANPLXB3_HUMANIntAct15184888 details
RON_HUMANRON_HUMANHPRD, IntAct10871856 22087277 details
RON_HUMANSHC1_HUMANBioGRID, HPRD8918464 details
RON_HUMANPLCG1_HUMANBioGRID, HPRD8918464 details
RON_HUMANHSP7C_HUMANBioGRID16740632 details
RON_HUMANHS90A_HUMANBioGRID16740632 details
RON_HUMANEPOR_HUMANBioGRID, HPRD14982882 details
RON_HUMAN1433G_HUMANBioGRID14505491 details
RON_HUMANYES_HUMANHPRD8918464 details
RON_HUMANP85A_HUMANHPRD8918464 details
RON_HUMANSRC_HUMANHPRD16103119 16166096 8918464 details
RON_HUMANHYAL2_HUMANHPRD12676986 details
RON_HUMANJAK2_HUMANHPRD14982882 details
RON_HUMANTF65_HUMANHPRD8918464 details