Entity Details

Primary name HLTF_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ14527
EntryNameHLTF_HUMAN
FullNameHelicase-like transcription factor
TaxID9606
Evidenceevidence at protein level
Length1009
SequenceStatuscomplete
DateCreated2005-03-01
DateModified2021-06-02

Ontological Relatives

GenesHLTF

GO terms

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GOName
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0006325 chromatin organization
GO:0008270 zinc ion binding
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
GO:0031625 ubiquitin protein ligase binding
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0061630 ubiquitin protein ligase activity
GO:0070615 nucleosome-dependent ATPase activity

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000330 SNF2, N-terminalDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014905 HIRAN domainDomainDomain
IPR017907 Zinc finger, RING-type, conserved siteSiteConserved site
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR038718 SNF2-like, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
HLTF_HUMANWBP4_HUMANBioGRID, MINT16055720 details
HLTF_HUMANUBE2Z_HUMANBioGRID, IntAct19690564 details
HLTF_HUMANCDK9_HUMANBioGRID, IntAct21988832 details
HLTF_HUMANHSP7C_HUMANBioGRID, IntAct21988832 details
HLTF_HUMANST1C2_HUMANBioGRID, IntAct21988832 details
HLTF_HUMANS10AA_HUMANBioGRID, IntAct23415230 details
HLTF_HUMANRAD18_HUMANBioGRID, DIP18316726 18719106 21396873 23555860 25023518 details
HLTF_HUMANUB2V2_HUMANBioGRID, DIP18316726 22904075 30696947 details
HLTF_HUMANUBE2N_HUMANBioGRID, DIP18316726 18719106 22904075 30696947 details
HLTF_HUMANPCNA_HUMANBioGRID, DIP18316726 18719106 22904075 26350214 28924044 30696947 31973093 32701997 details
HLTF_HUMANEWS_HUMANBioGRID, IntAct20211142 details
HLTF_HUMANCHFR_HUMANBioGRID19182791 20388495 details
HLTF_HUMANSP1_HUMANBioGRID10391891 details
HLTF_HUMANSP3_HUMANBioGRID10391891 details
HLTF_HUMANUBC_HUMANBioGRID22904075 details
HLTF_HUMANUBE2A_HUMANBioGRID22904075 details
HLTF_HUMANHLTF_HUMANBioGRID24198246 details
HLTF_HUMANDCAF1_HUMANBioGRID29079575 details
HLTF_HUMANEF1G_HUMANHPRD15383276 details
HLTF_HUMANBRF2_HUMANIntAct17353931 details
HLTF_HUMANPHLA3_HUMANIntAct17353931 details
HLTF_HUMANCIAO1_HUMANIntAct17353931 details
HLTF_HUMANSHPRH_HUMANBioGRID, DIP18719106 21396873 details
HLTF_HUMANFMR1_HUMANIntAct31413325 details
HLTF_HUMANRN146_HUMANBioGRID, MINT21799911 21825151 26186194 details
HLTF_HUMANSPRTN_HUMANBioGRID22902628 details
HLTF_HUMANDTL_HUMANBioGRID23555860 details
HLTF_HUMANBRCA1_HUMANBioGRID23901102 details
HLTF_HUMANRFA1_HUMANBioGRID24332808 24981860 26474068 27723720 details
HLTF_HUMANETAA1_HUMANBioGRID27723720 details
HLTF_HUMANNFAT5_HUMANBioGRID31376680 details
HLTF_HUMANRBMS1_HUMANBioGRID29395067 details
HLTF_HUMANNXF1_HUMANBioGRID29395067 details