Entity Details

Primary name RB3GP_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ15042
EntryNameRB3GP_HUMAN
FullNameRab3 GTPase-activating protein catalytic subunit
TaxID9606
Evidenceevidence at protein level
Length981
SequenceStatuscomplete
DateCreated2005-04-12
DateModified2021-06-02

Ontological Relatives

GenesRAB3GAP1

GO terms

Show/Hide Table
GOName
GO:0005096 GTPase activator activity
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005811 lipid droplet
GO:0005829 cytosol
GO:0007420 brain development
GO:0021854 hypothalamus development
GO:0031267 small GTPase binding
GO:0032991 protein-containing complex
GO:0034389 lipid droplet organization
GO:0043010 camera-type eye development
GO:0043087 regulation of GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0048172 regulation of short-term neuronal synaptic plasticity
GO:0060079 excitatory postsynaptic potential
GO:0060325 face morphogenesis
GO:0061646 positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization
GO:0070062 extracellular exosome
GO:0071782 endoplasmic reticulum tubular network
GO:0097051 establishment of protein localization to endoplasmic reticulum membrane
GO:0098794 postsynapse
GO:1903061 positive regulation of protein lipidation
GO:1903233 regulation of calcium ion-dependent exocytosis of neurotransmitter
GO:1903373 positive regulation of endoplasmic reticulum tubular network organization
GO:2000786 positive regulation of autophagosome assembly

Subcellular Location

Show/Hide Table
Subcellular Location
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR026147 Rab3 GTPase-activating protein catalytic subunitFamilyFamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
600118 OMIMWarburg micro syndrome 1 (WARBM1)A rare syndrome characterized by microcephaly, microphthalmia, microcornia, congenital cataracts, optic atrophy, cortical dysplasia, in particular corpus callosum hypoplasia, severe mental retardation, spastic diplegia, and hypogonadism. The disease is caused by variants affecting the gene represented in this entry.