Entity Details

Primary name A2ML1_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionA8K2U0
EntryNameA2ML1_HUMAN
FullNameAlpha-2-macroglobulin-like protein 1
TaxID9606
Evidenceevidence at protein level
Length1454
SequenceStatuscomplete
DateCreated2008-02-05
DateModified2021-06-02

Ontological Relatives

GenesA2ML1

GO terms

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GOName
GO:0002020 protease binding
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005615 extracellular space
GO:0030414 peptidase inhibitor activity
GO:0052548 regulation of endopeptidase activity
GO:0070062 extracellular exosome

Subcellular Location

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Subcellular Location
Secreted

Domains

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DomainNameCategoryType
IPR001599 Alpha-2-macroglobulinDomainDomain
IPR002890 Macroglobulin domainDomainDomain
IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroidFamilyHomologous superfamily
IPR009048 Alpha-macroglobulin, receptor-bindingDomainDomain
IPR011625 Alpha-2-macroglobulin, bait region domainDomainDomain
IPR011626 Alpha-macroglobulin-like, TED domainDomainDomain
IPR013783 Immunoglobulin-like foldFamilyHomologous superfamily
IPR014756 Immunoglobulin E-setFamilyHomologous superfamily
IPR019742 Alpha-2-macroglobulin, conserved siteSiteConserved site
IPR036595 Alpha-macroglobulin, receptor-binding domain superfamilyFamilyHomologous superfamily
IPR040839 Macroglobulin domain MG4DomainDomain
IPR041555 Macroglobulin domain MG3DomainDomain
IPR041813 Alpha-2-macroglobulin, TED domainDomainDomain

Diseases

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Disease IDSourceNameDescription
166760 OMIMOtitis media (OM)An inflammation of the middle ear resulting in earache, fever, hearing disturbance, and vertigo. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Interactions

0 interactions

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