Entity Details

Primary name FBX31_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ5XUX0
EntryNameFBX31_HUMAN
FullNameF-box only protein 31
TaxID9606
Evidenceevidence at protein level
Length539
SequenceStatuscomplete
DateCreated2005-02-15
DateModified2021-06-02

Ontological Relatives

GenesFBXO31

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0005813 centrosome
GO:0005829 cytosol
GO:0006974 cellular response to DNA damage stimulus
GO:0019005 SCF ubiquitin ligase complex
GO:0030332 cyclin binding
GO:0031145 anaphase-promoting complex-dependent catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031571 mitotic G1 DNA damage checkpoint signaling
GO:0043025 neuronal cell body
GO:0043687 post-translational protein modification
GO:0050775 positive regulation of dendrite morphogenesis
GO:2001224 positive regulation of neuron migration

Subcellular Location

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Domains

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DomainNameCategoryType
IPR001810 F-box domainDomainDomain
IPR026941 F-box only protein 31FamilyFamily
IPR036047 F-box-like domain superfamilyFamilyHomologous superfamily

Diseases

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Disease IDSourceNameDescription
615979 OMIMMental retardation, autosomal recessive 45 (MRT45)A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT45 manifestations include mild to moderate intellectual disability and dysmorphic features, including coarse facies, broad nasal bridge, fleshy nares, and thick, prominent lips. The disease is caused by variants affecting the gene represented in this entry.