Entity Details

Primary name AGRG6_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionQ86SQ4
EntryNameAGRG6_HUMAN
FullNameAdhesion G-protein coupled receptor G6
TaxID9606
Evidenceevidence at protein level
Length1221
SequenceStatuscomplete
DateCreated2004-07-19
DateModified2021-06-02

Ontological Relatives

GenesADGRG6

GO terms

Show/Hide Table
GOName
GO:0004930 G protein-coupled receptor activity
GO:0005518 collagen binding
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0007399 nervous system development
GO:0009986 cell surface
GO:0014037 Schwann cell differentiation
GO:0016021 integral component of membrane
GO:0019933 cAMP-mediated signaling
GO:0022011 myelination in peripheral nervous system
GO:0042552 myelination
GO:0043236 laminin binding
GO:0050840 extracellular matrix binding
GO:0060347 heart trabecula formation

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane

Domains

Show/Hide Table
DomainNameCategoryType
IPR000203 GPS motifDomainDomain
IPR000832 GPCR, family 2, secretin-likeFamilyFamily
IPR000859 CUB domainDomainDomain
IPR001759 Pentraxin-relatedFamilyFamily
IPR013320 Concanavalin A-like lectin/glucanase domain superfamilyFamilyHomologous superfamily
IPR017981 GPCR, family 2-likeDomainDomain
IPR017983 GPCR, family 2, secretin-like, conserved siteSiteConserved site
IPR035914 Spermadhesin, CUB domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table
Disease IDSourceNameDescription
616503 OMIMLethal congenital contracture syndrome 9 (LCCS9)A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. The disease is caused by variants affecting the gene represented in this entry.

Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink