Entity Details

Primary name MAOX_HUMAN
Entity type UniProt
Source Source Link

Details

AccessionP48163
EntryNameMAOX_HUMAN
FullNameNADP-dependent malic enzyme
TaxID9606
Evidenceevidence at protein level
Length572
SequenceStatuscomplete
DateCreated1996-02-01
DateModified2021-06-02

Ontological Relatives

GenesME1

GO terms

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GOName
GO:0004470 malic enzyme activity
GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity
GO:0004473 malate dehydrogenase (decarboxylating) (NADP+) activity
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005975 carbohydrate metabolic process
GO:0006090 pyruvate metabolic process
GO:0006108 malate metabolic process
GO:0008948 oxaloacetate decarboxylase activity
GO:0009055 electron transfer activity
GO:0009165 nucleotide biosynthetic process
GO:0009725 response to hormone
GO:0009743 response to carbohydrate
GO:0019222 regulation of metabolic process
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0043531 ADP binding
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:1902031 regulation of NADP metabolic process

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR001891 Malic oxidoreductaseFamilyFamily
IPR012301 Malic enzyme, N-terminal domainDomainDomain
IPR012302 Malic enzyme, NAD-bindingDomainDomain
IPR015884 Malic enzyme, conserved siteSiteConserved site
IPR036291 NAD(P)-binding domain superfamilyFamilyHomologous superfamily
IPR037062 Malic enzyme, N-terminal domain superfamilyFamilyHomologous superfamily

Diseases

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Drugs

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DrugNameSourceType
DB00157 NADHDrugbanksmall molecule
DB03461 Nicotinamide adenine dinucleotide phosphateDrugbanksmall molecule

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
MAOX_HUMANMAOX_HUMANBioGRID, IntAct32296183 details
MAOX_HUMANOGT1_HUMANBioGRID32994395 details