Entity Details

Primary name SMAD3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8BUN5
EntryNameSMAD3_MOUSE
FullNameMothers against decapentaplegic homolog 3
TaxID10090
Evidenceevidence at protein level
Length425
SequenceStatuscomplete
DateCreated2004-07-05
DateModified2021-06-02

Ontological Relatives

GenesSmad3

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0000976 transcription cis-regulatory region binding
GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001223 transcription coactivator binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001657 ureteric bud development
GO:0001666 response to hypoxia
GO:0001701 in utero embryonic development
GO:0001707 mesoderm formation
GO:0001756 somitogenesis
GO:0001889 liver development
GO:0001947 heart looping
GO:0002076 osteoblast development
GO:0002520 immune system development
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005160 transforming growth factor beta receptor binding
GO:0005518 collagen binding
GO:0005634 nucleus
GO:0005637 nuclear inner membrane
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006366 transcription by RNA polymerase II
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006955 immune response
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007183 SMAD protein complex assembly
GO:0007369 gastrulation
GO:0007492 endoderm development
GO:0008013 beta-catenin binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0008285 negative regulation of cell population proliferation
GO:0009653 anatomical structure morphogenesis
GO:0009880 embryonic pattern specification
GO:0010628 positive regulation of gene expression
GO:0010694 positive regulation of alkaline phosphatase activity
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0016202 regulation of striated muscle tissue development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0017151 DEAD/H-box RNA helicase binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019902 phosphatase binding
GO:0023019 signal transduction involved in regulation of gene expression
GO:0030154 cell differentiation
GO:0030308 negative regulation of cell growth
GO:0030325 adrenal gland development
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030509 BMP signaling pathway
GO:0030878 thyroid gland development
GO:0031490 chromatin DNA binding
GO:0031625 ubiquitin protein ligase binding
GO:0031962 mineralocorticoid receptor binding
GO:0032332 positive regulation of chondrocyte differentiation
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032909 regulation of transforming growth factor beta2 production
GO:0032916 positive regulation of transforming growth factor beta3 production
GO:0032924 activin receptor signaling pathway
GO:0032991 protein-containing complex
GO:0033689 negative regulation of osteoblast proliferation
GO:0035259 glucocorticoid receptor binding
GO:0038092 nodal signaling pathway
GO:0042110 T cell activation
GO:0042177 negative regulation of protein catabolic process
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043066 negative regulation of apoptotic process
GO:0043130 ubiquitin binding
GO:0043235 receptor complex
GO:0043425 bHLH transcription factor binding
GO:0043565 sequence-specific DNA binding
GO:0045216 cell-cell junction organization
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045668 negative regulation of osteoblast differentiation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046332 SMAD binding
GO:0048340 paraxial mesoderm morphogenesis
GO:0048589 developmental growth
GO:0048617 embryonic foregut morphogenesis
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0050678 regulation of epithelial cell proliferation
GO:0050728 negative regulation of inflammatory response
GO:0050776 regulation of immune response
GO:0050821 protein stabilization
GO:0050927 positive regulation of positive chemotaxis
GO:0051098 regulation of binding
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051496 positive regulation of stress fiber assembly
GO:0051894 positive regulation of focal adhesion assembly
GO:0060039 pericardium development
GO:0060290 transdifferentiation
GO:0060395 SMAD protein signal transduction
GO:0061045 negative regulation of wound healing
GO:0061767 negative regulation of lung blood pressure
GO:0070306 lens fiber cell differentiation
GO:0070410 co-SMAD binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0071141 SMAD protein complex
GO:0071144 heteromeric SMAD protein complex
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
GO:1901203 positive regulation of extracellular matrix assembly
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:1903243 negative regulation of cardiac muscle hypertrophy in response to stress

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR001132 SMAD domain, Dwarfin-typeDomainDomain
IPR003619 MAD homology 1, Dwarfin-typeDomainDomain
IPR008984 SMAD/FHA domain superfamilyFamilyHomologous superfamily
IPR013019 MAD homology, MH1DomainDomain
IPR013790 DwarfinFamilyFamily
IPR017855 SMAD-like domain superfamilyFamilyHomologous superfamily
IPR036578 SMAD MH1 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

28 interactions

InteractorPartnerSourcesPublicationsLink
SMAD3_MOUSESMAD4_MOUSEBioGRID, DIP, IntAct, MINT12145309 12672795 14764653 17226765 18268325 21145499 22036565 22045334 22442258 details
SMAD3_MOUSEMYOD1_MOUSEBioGRID, IntAct11711431 20211142 22036565 details
SMAD3_MOUSEFOXH1_MOUSEBioGRID20211142 details
SMAD3_MOUSEVDR_MOUSEBioGRID20211142 details
SMAD3_MOUSEGATA4_MOUSEBioGRID14662776 details
SMAD3_MOUSEJUN_MOUSEBioGRID22610349 details
SMAD3_MOUSEMAGI2_MOUSEBioGRID10681527 details
SMAD3_MOUSEERBIN_MOUSEMINT12650946 details
SMAD3_MOUSEAXIN1_HUMANMINT16601693 details
SMAD3_MOUSEAXIN1_MOUSEBioGRID, MINT16601693 details
SMAD3_MOUSESMAD7_MOUSEBioGRID, IntAct19914168 22036565 30315770 details
SMAD3_MOUSEPO5F1_MOUSEIntAct22036565 details
SMAD3_MOUSEUBC_HUMANMINT22045334 details
SMAD3_MOUSECO1A1_MOUSEBioGRID, IntAct14559231 27728806 details
SMAD3_MOUSEGSK3B_MOUSEBioGRID18172167 details
SMAD3_MOUSESNAI1_MOUSEBioGRID19597490 details
SMAD3_MOUSEHIF1A_MOUSEBioGRID17053163 details
SMAD3_MOUSEPEX6_MOUSEBioGRID14651998 details
SMAD3_MOUSE4ET_MOUSEBioGRID14651998 details
SMAD3_MOUSEZMYM2_MOUSEBioGRID14651998 details
SMAD3_MOUSEPBX1_MOUSEBioGRID14764653 details
SMAD3_MOUSEPKNX1_MOUSEBioGRID14764653 details
SMAD3_MOUSECO3A1_MOUSEBioGRID14559231 details
SMAD3_MOUSECO5A1_MOUSEBioGRID14559231 details
SMAD3_MOUSEYAP1_MOUSEBioGRID21145499 details
SMAD3_MOUSEOTUB1_MOUSEBioGRID24071738 details
SMAD3_MOUSETGFI1_MOUSEBioGRID14755691 details
SMAD3_MOUSECYLD_MOUSEBioGRID30315770 details