Entity Details

Primary name NSD2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8BVE8
EntryNameNSD2_MOUSE
FullNameHistone-lysine N-methyltransferase NSD2
TaxID10090
Evidenceevidence at protein level
Length1365
SequenceStatuscomplete
DateCreated2006-10-31
DateModified2021-06-02

Ontological Relatives

GenesNsd2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000785 chromatin
GO:0003149 membranous septum morphogenesis
GO:0003289 atrial septum primum morphogenesis
GO:0003290 atrial septum secundum morphogenesis
GO:0003682 chromatin binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0006355 regulation of transcription, DNA-templated
GO:0010452 histone H3-K36 methylation
GO:0018024 histone-lysine N-methyltransferase activity
GO:0034770 histone H4-K20 methylation
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046975 histone methyltransferase activity (H3-K36 specific)
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0060348 bone development
GO:0070201 regulation of establishment of protein localization
GO:2001032 regulation of double-strand break repair via nonhomologous end joining

Subcellular Location

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Subcellular Location
Chromosome
Nucleus

Domains

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DomainNameCategoryType
IPR000313 PWWP domainDomainDomain
IPR001214 SET domainDomainDomain
IPR001841 Zinc finger, RING-typeDomainDomain
IPR001965 Zinc finger, PHD-typeDomainDomain
IPR003616 Post-SET domainDomainDomain
IPR006560 AWS domainDomainDomain
IPR009071 High mobility group box domainDomainDomain
IPR011011 Zinc finger, FYVE/PHD-typeFamilyHomologous superfamily
IPR013083 Zinc finger, RING/FYVE/PHD-typeFamilyHomologous superfamily
IPR019786 Zinc finger, PHD-type, conserved siteSiteConserved site
IPR019787 Zinc finger, PHD-fingerDomainDomain
IPR036910 High mobility group box domain superfamilyFamilyHomologous superfamily
IPR041306 NSD, Cys-His rich domainDomainDomain

Diseases

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