Entity Details

Primary name DOCK8_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8C147
EntryNameDOCK8_MOUSE
FullNameDedicator of cytokinesis protein 8
TaxID10090
Evidenceevidence at protein level
Length2100
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesDock8

GO terms

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GOName
GO:0001771 immunological synapse formation
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0007264 small GTPase mediated signal transduction
GO:0031252 cell leading edge
GO:0031256 leading edge membrane
GO:0031258 lamellipodium membrane
GO:0036336 dendritic cell migration
GO:0043547 positive regulation of GTPase activity
GO:0061485 memory T cell proliferation
GO:0070233 negative regulation of T cell apoptotic process
GO:1903905 positive regulation of establishment of T cell polarity
GO:1990869 cellular response to chemokine
GO:2000406 positive regulation of T cell migration

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm

Domains

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DomainNameCategoryType
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR021816 Dedicator of cytokinesis C/D, N-terminalDomainDomain
IPR026791 Dedicator of cytokinesisFamilyFamily
IPR027007 C2 DOCK-type domainDomainDomain
IPR027357 DOCKER domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR037808 Dedicator of cytokinesis C, C2 domainDomainDomain
IPR043161 Dedicator of cytokinesis, C-terminal, lobe AFamilyHomologous superfamily
IPR043162 Dedicator of cytokinesis, C-terminal, lobe CFamilyHomologous superfamily

Diseases

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Interactions

0 interactions

InteractorPartnerSourcesPublicationsLink