Entity Details

Primary name CHK1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO35280
EntryNameCHK1_MOUSE
FullNameSerine/threonine-protein kinase Chk1
TaxID10090
Evidenceevidence at protein level
Length476
SequenceStatuscomplete
DateCreated2000-05-30
DateModified2021-06-02

Ontological Relatives

GenesChek1

GO terms

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GOName
GO:0000077 DNA damage checkpoint signaling
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000785 chromatin
GO:0000794 condensed nuclear chromosome
GO:0001833 inner cell mass cell proliferation
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005657 replication fork
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0006281 DNA repair
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
GO:0006975 DNA damage induced protein phosphorylation
GO:0006997 nucleus organization
GO:0010468 regulation of gene expression
GO:0010569 regulation of double-strand break repair via homologous recombination
GO:0010767 regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle
GO:0018107 peptidyl-threonine phosphorylation
GO:0019904 protein domain specific binding
GO:0032991 protein-containing complex
GO:0035402 histone kinase activity (H3-T11 specific)
GO:0035556 intracellular signal transduction
GO:0042127 regulation of cell population proliferation
GO:0043231 intracellular membrane-bounded organelle
GO:0044818 mitotic G2/M transition checkpoint
GO:0045787 positive regulation of cell cycle
GO:0045839 negative regulation of mitotic nuclear division
GO:0046602 regulation of mitotic centrosome separation
GO:0048096 chromatin-mediated maintenance of transcription
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:1902742 apoptotic process involved in development
GO:2000279 negative regulation of DNA biosynthetic process
GO:2000615 regulation of histone H3-K9 acetylation

Subcellular Location

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Subcellular Location
Chromosome
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR034670 Checkpoint kinase 1, catalytic domainDomainDomain

Diseases

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Interactions

4 interactions