Entity Details

Primary name DOCK2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8C3J5
EntryNameDOCK2_MOUSE
FullNameDedicator of cytokinesis protein 2
TaxID10090
Evidenceevidence at protein level
Length1828
SequenceStatuscomplete
DateCreated2003-07-03
DateModified2021-06-02

Ontological Relatives

GenesDock2

GO terms

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GOName
GO:0001766 membrane raft polarization
GO:0001768 establishment of T cell polarity
GO:0001771 immunological synapse formation
GO:0002277 myeloid dendritic cell activation involved in immune response
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0006935 chemotaxis
GO:0007010 cytoskeleton organization
GO:0007264 small GTPase mediated signal transduction
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0030036 actin cytoskeleton organization
GO:0035022 positive regulation of Rac protein signal transduction
GO:0042098 T cell proliferation
GO:0042110 T cell activation
GO:0042608 T cell receptor binding
GO:0044351 macropinocytosis
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0046631 alpha-beta T cell activation
GO:0046633 alpha-beta T cell proliferation
GO:0050766 positive regulation of phagocytosis

Subcellular Location

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Subcellular Location
Cytoplasm
Endomembrane system

Domains

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DomainNameCategoryType
IPR001452 SH3 domainDomainDomain
IPR016024 Armadillo-type foldFamilyHomologous superfamily
IPR026791 Dedicator of cytokinesisFamilyFamily
IPR026799 Dedicator of cytokinesis protein 2FamilyFamily
IPR027007 C2 DOCK-type domainDomainDomain
IPR027357 DOCKER domainDomainDomain
IPR032376 Dedicator of cytokinesis, N-terminal domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR042455 Dedicator of cytokinesis, N-terminal, subdomain 1FamilyHomologous superfamily
IPR043161 Dedicator of cytokinesis, C-terminal, lobe AFamilyHomologous superfamily
IPR043162 Dedicator of cytokinesis, C-terminal, lobe CFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
DOCK2_MOUSEELMO1_MOUSEIntAct15102471 details