Entity Details

Primary name ITCH_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8C863
EntryNameITCH_MOUSE
FullNameE3 ubiquitin-protein ligase Itchy
TaxID10090
Evidenceevidence at protein level
Length864
SequenceStatuscomplete
DateCreated2003-10-03
DateModified2021-06-02

Ontological Relatives

GenesItch

GO terms

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GOName
GO:0000151 ubiquitin ligase complex
GO:0000209 protein polyubiquitination
GO:0002669 positive regulation of T cell anergy
GO:0004842 ubiquitin-protein transferase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006915 apoptotic process
GO:0016020 membrane
GO:0016567 protein ubiquitination
GO:0016874 ligase activity
GO:0031410 cytoplasmic vesicle
GO:0031901 early endosome membrane
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032991 protein-containing complex
GO:0035519 protein K29-linked ubiquitination
GO:0043021 ribonucleoprotein complex binding
GO:0043066 negative regulation of apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043231 intracellular membrane-bounded organelle
GO:0044389 ubiquitin-like protein ligase binding
GO:0045087 innate immune response
GO:0045236 CXCR chemokine receptor binding
GO:0045732 positive regulation of protein catabolic process
GO:0046329 negative regulation of JNK cascade
GO:0046642 negative regulation of alpha-beta T cell proliferation
GO:0050687 negative regulation of defense response to virus
GO:0051607 defense response to virus
GO:0051865 protein autoubiquitination
GO:0061630 ubiquitin protein ligase activity
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0090085 regulation of protein deubiquitination
GO:1990763 arrestin family protein binding
GO:2000646 positive regulation of receptor catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Early endosome membrane
Endosome membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000569 HECT domainDomainDomain
IPR001202 WW domainDomainDomain
IPR024928 E3 ubiquitin-protein ligase, SMURF1 typeFamilyFamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR035983 HECT, E3 ligase catalytic domainFamilyHomologous superfamily
IPR036020 WW domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
ITCH_MOUSECFLAR_MOUSEBioGRID, IntAct16469705 details
ITCH_MOUSENOTC1_MOUSEBioGRID, InnateDB10940313 21478879 details
ITCH_MOUSEBIG2_HUMANBioGRID18832381 details
ITCH_MOUSEUB2L3_HUMANBioGRID10940313 details
ITCH_MOUSEGLIS3_HUMANBioGRID26147758 details
ITCH_MOUSELRAD3_HUMANBioGRID26854353 details
ITCH_MOUSESHOT1_MOUSEBioGRID28981589 details
ITCH_MOUSETGFI1_MOUSEBioGRID28612841 details
ITCH_MOUSERBP1_MOUSEMINT19131965 details
ITCH_MOUSEGLI1_MOUSEBioGRID, I2D20818436 30675521 details
ITCH_MOUSETRAF2_MOUSEBioGRID, InnateDB20185725 21765415 details
ITCH_MOUSETRAF6_MOUSEBioGRID, InnateDB18246070 20185725 21765415 23782702 details
ITCH_MOUSETAXB1_MOUSEBioGRID, InnateDB21765415 27736772 details
ITCH_MOUSERIPK1_MOUSEBioGRID, InnateDB18246070 21765415 details
ITCH_MOUSECYLD_MOUSEBioGRID, InnateDB22057290 23782702 details
ITCH_MOUSESF01_HUMANIntAct26420826 details
ITCH_MOUSEKLF10_MOUSEIntAct18278048 details
ITCH_MOUSENOTC1_HUMANBioGRID18628966 details
ITCH_MOUSEJUN_MOUSEBioGRID16901904 details
ITCH_MOUSEJUNB_MOUSEBioGRID16387660 details
ITCH_MOUSEPTN11_MOUSEBioGRID20417562 details
ITCH_MOUSESMAD2_MOUSEBioGRID15350225 details
ITCH_MOUSENFIP1_MOUSEBioGRID17137798 details
ITCH_MOUSETAB1_MOUSEBioGRID25714464 details
ITCH_MOUSELRAD3_MOUSEBioGRID26854353 details
ITCH_MOUSERORG_MOUSEBioGRID27322655 details
ITCH_MOUSECXCR4_MOUSEBioGRID28264927 details
ITCH_MOUSEMAVS_MOUSEBioGRID27736772 32325033 details
ITCH_MOUSEDPYL2_MOUSEBioGRID27940916 details
ITCH_MOUSESUFU_MOUSEBioGRID29515120 details
ITCH_MOUSEARRB2_MOUSEBioGRID29515120 32325033 details
ITCH_MOUSEGLI1_HUMANBioGRID30675521 details
ITCH_MOUSEWBP1L_MOUSEBioGRID31845480 details