Entity Details

Primary name CAN1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO35350
EntryNameCAN1_MOUSE
FullNameCalpain-1 catalytic subunit
TaxID10090
Evidenceevidence at protein level
Length713
SequenceStatuscomplete
DateCreated2001-01-11
DateModified2021-06-02

Ontological Relatives

GenesCapn1

GO terms

Show/Hide Table
GOName
GO:0004198 calcium-dependent cysteine-type endopeptidase activity
GO:0005509 calcium ion binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005764 lysosome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006508 proteolysis
GO:0008092 cytoskeletal protein binding
GO:0008233 peptidase activity
GO:0010666 positive regulation of cardiac muscle cell apoptotic process
GO:0016020 membrane
GO:0016540 protein autoprocessing
GO:0019899 enzyme binding
GO:0030837 negative regulation of actin filament polymerization
GO:0032801 receptor catabolic process
GO:0043117 positive regulation of vascular permeability
GO:0050790 regulation of catalytic activity
GO:0060056 mammary gland involution
GO:0070301 cellular response to hydrogen peroxide
GO:0097264 self proteolysis
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:1903238 positive regulation of leukocyte tethering or rolling
GO:1990776 response to angiotensin

Subcellular Location

Show/Hide Table
Subcellular Location
Cell membrane
Cytoplasm

Domains

Show/Hide Table
DomainNameCategoryType
IPR000169 Cysteine peptidase, cysteine active siteSiteActive site
IPR001300 Peptidase C2, calpain, catalytic domainDomainDomain
IPR002048 EF-hand domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR018247 EF-Hand 1, calcium-binding siteSiteBinding site
IPR022682 Peptidase C2, calpain, large subunit, domain IIIDomainDomain
IPR022683 Peptidase C2, calpain, domain IIIDomainDomain
IPR022684 Peptidase C2, calpain familyFamilyFamily
IPR029643 Calpain-1FamilyFamily
IPR033883 Calpain subdomain IIIDomainDomain
IPR036213 Calpain large subunit, domain III superfamilyFamilyHomologous superfamily
IPR038765 Papain-like cysteine peptidase superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
CAN1_MOUSEPTN5_MOUSEBioGRID19625523 details
CAN1_MOUSETIRAP_HUMANInnateDB23023391 details