Entity Details

Primary name PDE5A_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8CG03
EntryNamePDE5A_MOUSE
FullNamecGMP-specific 3',5'-cyclic phosphodiesterase
TaxID10090
Evidenceevidence at protein level
Length865
SequenceStatuscomplete
DateCreated2003-09-26
DateModified2021-06-02

Ontological Relatives

GenesPde5a

GO terms

Show/Hide Table
GOName
GO:0002026 regulation of the force of heart contraction
GO:0002678 positive regulation of chronic inflammatory response
GO:0004112 cyclic-nucleotide phosphodiesterase activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0005829 cytosol
GO:0007165 signal transduction
GO:0007614 short-term memory
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010749 regulation of nitric oxide mediated signal transduction
GO:0030553 cGMP binding
GO:0042130 negative regulation of T cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0043406 positive regulation of MAP kinase activity
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
GO:0045907 positive regulation of vasoconstriction
GO:0046068 cGMP metabolic process
GO:0046069 cGMP catabolic process
GO:0046872 metal ion binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0055118 negative regulation of cardiac muscle contraction
GO:0055119 relaxation of cardiac muscle
GO:0060282 positive regulation of oocyte development

Subcellular Location

Show/Hide Table

Domains

Show/Hide Table
DomainNameCategoryType
IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domainDomainDomain
IPR003018 GAF domainDomainDomain
IPR003607 HD/PDEase domainDomainDomain
IPR023088 3'5'-cyclic nucleotide phosphodiesteraseFamilyFamily
IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved siteSiteConserved site
IPR029016 GAF-like domain superfamilyFamilyHomologous superfamily
IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
PDE5A_MOUSEPP1A_MOUSEbhf-ucl, BioGRID25593058 29669786 details