Entity Details

Primary name PLCG2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8CIH5
EntryNamePLCG2_MOUSE
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
TaxID10090
Evidenceevidence at protein level
Length1265
SequenceStatuscomplete
DateCreated2008-07-01
DateModified2021-06-02

Ontological Relatives

GenesPlcg2

GO terms

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GOName
GO:0001784 phosphotyrosine residue binding
GO:0002092 positive regulation of receptor internalization
GO:0002316 follicular B cell differentiation
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006661 phosphatidylinositol biosynthetic process
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0009395 phospholipid catabolic process
GO:0010468 regulation of gene expression
GO:0010634 positive regulation of epithelial cell migration
GO:0016020 membrane
GO:0019722 calcium-mediated signaling
GO:0019901 protein kinase binding
GO:0030183 B cell differentiation
GO:0032026 response to magnesium ion
GO:0032237 activation of store-operated calcium channel activity
GO:0032481 positive regulation of type I interferon production
GO:0032496 response to lipopolysaccharide
GO:0032959 inositol trisphosphate biosynthetic process
GO:0033198 response to ATP
GO:0043069 negative regulation of programmed cell death
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0071277 cellular response to calcium ion
GO:0097110 scaffold protein binding
GO:0140031 phosphorylation-dependent protein binding

Subcellular Location

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Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR000980 SH2 domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001452 SH3 domainDomainDomain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR001849 Pleckstrin homology domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR011993 PH-like domain superfamilyFamilyHomologous superfamily
IPR016279 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gammaFamilyFamily
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR028381 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2FamilyFamily
IPR035023 PLC-gamma, C-terminal SH2 domainDomainDomain
IPR035024 PLC-gamma, N-terminal SH2 domainDomainDomain
IPR035723 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domainDomainDomain
IPR035892 C2 domain superfamilyFamilyHomologous superfamily
IPR036028 SH3-like domain superfamilyFamilyHomologous superfamily
IPR036860 SH2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

33 interactions

InteractorPartnerSourcesPublicationsLink
PLCG2_MOUSEGELS_MOUSEIntAct15102471 details
PLCG2_MOUSENDC80_MOUSEIntAct15102471 details
PLCG2_MOUSEPDC6I_MOUSEIntAct15102471 details
PLCG2_MOUSECAP1_MOUSEIntAct15102471 details
PLCG2_MOUSEDVL2_MOUSEIntAct15102471 details
PLCG2_MOUSEFINC_MOUSEIntAct15102471 details
PLCG2_MOUSEFLNA_MOUSEIntAct15102471 details
PLCG2_MOUSETRI27_MOUSEIntAct15102471 details
PLCG2_MOUSESPY2_MOUSEIntAct15102471 details
PLCG2_MOUSEUCK1_MOUSEIntAct15102471 details
PLCG2_MOUSESPTB2_MOUSEIntAct15102471 details
PLCG2_MOUSEBACH2_MOUSEIntAct15102471 details
PLCG2_MOUSEPHC2_MOUSEIntAct15102471 details
PLCG2_MOUSETOX4_MOUSEIntAct15102471 details
PLCG2_MOUSEHAX1_MOUSEIntAct15102471 details
PLCG2_MOUSENBR1_MOUSEIntAct15102471 details
PLCG2_MOUSEREPS1_MOUSEIntAct15102471 details
PLCG2_MOUSESH3K1_MOUSEIntAct15102471 details
PLCG2_MOUSESHIP1_MOUSEIntAct15102471 details
PLCG2_MOUSEDYLT1_MOUSEIntAct15102471 details
PLCG2_MOUSEZBT7B_MOUSEIntAct15102471 details
PLCG2_MOUSEE41L2_MOUSEIntAct15102471 details
PLCG2_MOUSESOS2_MOUSEIntAct15102471 details
PLCG2_MOUSEERRFI_MOUSEIntAct15102471 details
PLCG2_MOUSEFHL2_MOUSEIntAct15102471 details
PLCG2_MOUSECRYAB_MOUSEIntAct15102471 details
PLCG2_MOUSECSF1R_HUMANMINT9312046 details
PLCG2_MOUSECSF1R_MOUSEBioGRID9312046 details
PLCG2_MOUSEITB2_MOUSEBioGRID30333137 details
PLCG2_MOUSEEPOR_MOUSEIntAct15953601 details
PLCG2_MOUSELYN_MOUSEMINT8395016 details
PLCG2_MOUSEBLK_MOUSEMINT8395016 details
PLCG2_MOUSEFYN_MOUSEMINT8395016 details