Entity Details

Primary name PAK2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8CIN4
EntryNamePAK2_MOUSE
FullNameSerine/threonine-protein kinase PAK 2
TaxID10090
Evidenceevidence at protein level
Length524
SequenceStatuscomplete
DateCreated2004-04-13
DateModified2021-06-02

Ontological Relatives

GenesPak2

GO terms

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GOName
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0014069 postsynaptic density
GO:0016020 membrane
GO:0016310 phosphorylation
GO:0018105 peptidyl-serine phosphorylation
GO:0019901 protein kinase binding
GO:0030296 protein tyrosine kinase activator activity
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031267 small GTPase binding
GO:0032147 activation of protein kinase activity
GO:0034333 adherens junction assembly
GO:0040008 regulation of growth
GO:0042802 identical protein binding
GO:0043066 negative regulation of apoptotic process
GO:0046777 protein autophosphorylation
GO:0048471 perinuclear region of cytoplasm
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050770 regulation of axonogenesis
GO:0051493 regulation of cytoskeleton organization
GO:0051497 negative regulation of stress fiber assembly
GO:0060996 dendritic spine development
GO:0070830 bicellular tight junction assembly
GO:0071407 cellular response to organic cyclic compound
GO:0098978 glutamatergic synapse
GO:0106310 protein serine kinase activity
GO:0106311 protein threonine kinase activity
GO:0150105 protein localization to cell-cell junction
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis

Subcellular Location

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Subcellular Location
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR000095 CRIB domainDomainDomain
IPR000719 Protein kinase domainDomainDomain
IPR008271 Serine/threonine-protein kinase, active siteSiteActive site
IPR011009 Protein kinase-like domain superfamilyFamilyHomologous superfamily
IPR017441 Protein kinase, ATP binding siteSiteBinding site
IPR033923 p21 activated kinase binding domainDomainDomain
IPR035064 p21-activated kinase 2, catalytic domainDomainDomain
IPR035065 Serine/threonine-protein kinase PAK2FamilyFamily
IPR036936 CRIB domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

4 interactions