Entity Details

Primary name NOTC2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO35516
EntryNameNOTC2_MOUSE
FullNameNeurogenic locus notch homolog protein 2
TaxID10090
Evidenceevidence at protein level
Length2473
SequenceStatuscomplete
DateCreated2002-03-27
DateModified2021-06-02

Ontological Relatives

GenesNotch2

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0001501 skeletal system development
GO:0001701 in utero embryonic development
GO:0001709 cell fate determination
GO:0001889 liver development
GO:0001890 placenta development
GO:0001947 heart looping
GO:0002011 morphogenesis of an epithelial sheet
GO:0002315 marginal zone B cell differentiation
GO:0002437 inflammatory response to antigenic stimulus
GO:0003184 pulmonary valve morphogenesis
GO:0005509 calcium ion binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005929 cilium
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006959 humoral immune response
GO:0007219 Notch signaling pathway
GO:0007368 determination of left/right symmetry
GO:0007417 central nervous system development
GO:0008284 positive regulation of cell population proliferation
GO:0009887 animal organ morphogenesis
GO:0009986 cell surface
GO:0010629 negative regulation of gene expression
GO:0010838 positive regulation of keratinocyte proliferation
GO:0019899 enzyme binding
GO:0030326 embryonic limb morphogenesis
GO:0030513 positive regulation of BMP signaling pathway
GO:0031012 extracellular matrix
GO:0035264 multicellular organism growth
GO:0035622 intrahepatic bile duct development
GO:0038023 signaling receptor activity
GO:0042060 wound healing
GO:0042742 defense response to bacterium
GO:0043011 myeloid dendritic cell differentiation
GO:0043065 positive regulation of apoptotic process
GO:0043235 receptor complex
GO:0045672 positive regulation of osteoclast differentiation
GO:0045967 negative regulation of growth rate
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046849 bone remodeling
GO:0051059 NF-kappaB binding
GO:0060413 atrial septum morphogenesis
GO:0060674 placenta blood vessel development
GO:0061073 ciliary body morphogenesis
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070986 left/right axis specification
GO:0072014 proximal tubule development
GO:0072015 glomerular visceral epithelial cell development
GO:0072104 glomerular capillary formation
GO:0072574 hepatocyte proliferation
GO:0072576 liver morphogenesis
GO:1990705 cholangiocyte proliferation
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2001204 regulation of osteoclast development

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000152 EGF-type aspartate/asparagine hydroxylation sitePTMPTM
IPR000742 EGF-like domainDomainDomain
IPR000800 Notch domainDomainDomain
IPR001881 EGF-like calcium-binding domainDomainDomain
IPR002110 Ankyrin repeatRepeatRepeat
IPR008297 NotchFamilyFamily
IPR009030 Growth factor receptor cysteine-rich domain superfamilyFamilyHomologous superfamily
IPR010660 Notch, NOD domainDomainDomain
IPR011656 Notch, NODP domainDomainDomain
IPR013032 EGF-like, conserved siteSiteConserved site
IPR018097 EGF-like calcium-binding, conserved siteSiteConserved site
IPR020683 Ankyrin repeat-containing domainDomainDomain
IPR022336 Neurogenic locus Notch 2FamilyFamily
IPR024600 Domain of unknown function DUF3454, notchDomainDomain
IPR035993 Notch-like domain superfamilyFamilyHomologous superfamily
IPR036770 Ankyrin repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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