Entity Details

Primary name AGO3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8CJF9
EntryNameAGO3_MOUSE
FullNameProtein argonaute-3
TaxID10090
Evidenceevidence at transcript level
Length860
SequenceStatuscomplete
DateCreated2003-11-14
DateModified2021-06-02

Ontological Relatives

GenesAgo3

GO terms

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GOName
GO:0000794 condensed nuclear chromosome
GO:0000932 P-body
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0004521 endoribonuclease activity
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0006402 mRNA catabolic process
GO:0010501 RNA secondary structure unwinding
GO:0010628 positive regulation of gene expression
GO:0016442 RISC complex
GO:0031054 pre-miRNA processing
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035198 miRNA binding
GO:0035278 miRNA mediated inhibition of translation
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0046872 metal ion binding
GO:0070578 RISC-loading complex
GO:0072091 regulation of stem cell proliferation
GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA
GO:1901224 positive regulation of NIK/NF-kappaB signaling

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR003100 PAZ domainDomainDomain
IPR003165 Piwi domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014811 Argonaute, linker 1 domainDomainDomain
IPR028603 Protein argonaute-3FamilyFamily
IPR032472 Argonaute linker 2 domainDomainDomain
IPR032473 Protein argonaute, Mid domainDomainDomain
IPR032474 Protein argonaute, N-terminalDomainDomain
IPR036085 PAZ domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
AGO3_MOUSEOTUD4_HUMANBioGRID31138677 details