Entity Details

Primary name AGO2_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8CJG0
EntryNameAGO2_MOUSE
FullNameProtein argonaute-2
TaxID10090
Evidenceevidence at protein level
Length860
SequenceStatuscomplete
DateCreated2003-11-14
DateModified2021-06-02

Ontological Relatives

GenesAgo2

GO terms

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GOName
GO:0000340 RNA 7-methylguanosine cap binding
GO:0000932 P-body
GO:0000993 RNA polymerase II complex binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003727 single-stranded RNA binding
GO:0003729 mRNA binding
GO:0004521 endoribonuclease activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005844 polysome
GO:0005845 mRNA cap binding complex
GO:0008022 protein C-terminus binding
GO:0009791 post-embryonic development
GO:0010501 RNA secondary structure unwinding
GO:0010586 miRNA metabolic process
GO:0010628 positive regulation of gene expression
GO:0016442 RISC complex
GO:0030154 cell differentiation
GO:0030425 dendrite
GO:0031047 gene silencing by RNA
GO:0031054 pre-miRNA processing
GO:0035087 siRNA loading onto RISC involved in RNA interference
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0035278 miRNA mediated inhibition of translation
GO:0035279 mRNA cleavage involved in gene silencing by miRNA
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042985 negative regulation of amyloid precursor protein biosynthetic process
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0045947 negative regulation of translational initiation
GO:0045975 positive regulation of translation, ncRNA-mediated
GO:0046872 metal ion binding
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070062 extracellular exosome
GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA
GO:0070578 RISC-loading complex
GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA
GO:0090625 mRNA cleavage involved in gene silencing by siRNA
GO:0098808 mRNA cap binding
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:1901165 positive regulation of trophoblast cell migration
GO:1905618 positive regulation of miRNA mediated inhibition of translation
GO:1990904 ribonucleoprotein complex

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR003100 PAZ domainDomainDomain
IPR003165 Piwi domainDomainDomain
IPR012337 Ribonuclease H-like superfamilyFamilyHomologous superfamily
IPR014811 Argonaute, linker 1 domainDomainDomain
IPR028602 Protein argonaute-2FamilyFamily
IPR032472 Argonaute linker 2 domainDomainDomain
IPR032473 Protein argonaute, Mid domainDomainDomain
IPR032474 Protein argonaute, N-terminalDomainDomain
IPR036085 PAZ domain superfamilyFamilyHomologous superfamily
IPR036397 Ribonuclease H superfamilyFamilyHomologous superfamily

Diseases

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