Entity Details

Primary name HMCS1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8JZK9
EntryNameHMCS1_MOUSE
FullNameHydroxymethylglutaryl-CoA synthase, cytoplasmic
TaxID10090
Evidenceevidence at protein level
Length520
SequenceStatuscomplete
DateCreated2005-03-15
DateModified2021-06-02

Ontological Relatives

GenesHmgcs1

GO terms

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GOName
GO:0001889 liver development
GO:0004421 hydroxymethylglutaryl-CoA synthase activity
GO:0005829 cytosol
GO:0006084 acetyl-CoA metabolic process
GO:0006695 cholesterol biosynthetic process
GO:0007420 brain development
GO:0008584 male gonad development
GO:0009645 response to low light intensity stimulus
GO:0010142 farnesyl diphosphate biosynthetic process, mevalonate pathway
GO:0014074 response to purine-containing compound
GO:0016853 isomerase activity
GO:0033197 response to vitamin E
GO:0036094 small molecule binding
GO:0042493 response to drug
GO:0042803 protein homodimerization activity
GO:0043177 organic acid binding
GO:0046690 response to tellurium ion
GO:0071372 cellular response to follicle-stimulating hormone stimulus
GO:0071397 cellular response to cholesterol
GO:0071404 cellular response to low-density lipoprotein particle stimulus

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active siteSiteActive site
IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryoticFamilyFamily
IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminalDomainDomain
IPR013746 Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domainDomainDomain
IPR016039 Thiolase-likeFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HMCS1_MOUSEHCD2_HUMANBioGRID22496890 details