Entity Details

Primary name CDC73_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8JZM7
EntryNameCDC73_MOUSE
FullNameParafibromin
TaxID10090
Evidenceevidence at protein level
Length531
SequenceStatuscomplete
DateCreated2005-12-20
DateModified2021-06-02

Ontological Relatives

GenesCdc73

GO terms

Show/Hide Table
GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000993 RNA polymerase II complex binding
GO:0001558 regulation of cell growth
GO:0001711 endodermal cell fate commitment
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006368 transcription elongation from RNA polymerase II promoter
GO:0006378 mRNA polyadenylation
GO:0007049 cell cycle
GO:0008285 negative regulation of cell population proliferation
GO:0010390 histone monoubiquitination
GO:0016055 Wnt signaling pathway
GO:0016593 Cdc73/Paf1 complex
GO:0019827 stem cell population maintenance
GO:0030177 positive regulation of Wnt signaling pathway
GO:0031442 positive regulation of mRNA 3'-end processing
GO:0031648 protein destabilization
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0034402 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
GO:0043066 negative regulation of apoptotic process
GO:0045638 negative regulation of myeloid cell differentiation
GO:0048147 negative regulation of fibroblast proliferation
GO:0050680 negative regulation of epithelial cell proliferation
GO:0071222 cellular response to lipopolysaccharide
GO:1902808 positive regulation of cell cycle G1/S phase transition
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle

Subcellular Location

Show/Hide Table
Subcellular Location
Nucleus

Domains

Show/Hide Table
DomainNameCategoryType
IPR007852 Cdc73/ParafibrominFamilyFamily
IPR031336 Cell division control protein 73, C-terminalDomainDomain
IPR032041 Paf1 complex subunit Cdc73, N-terminal domainDomainDomain
IPR038103 Cell division control protein 73, C-terminal domain superfamilyFamilyHomologous superfamily

Diseases

Show/Hide Table

Interactions

4 interactions