Entity Details

Primary name AXIN1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionO35625
EntryNameAXIN1_MOUSE
FullNameAxin-1
TaxID10090
Evidenceevidence at protein level
Length863
SequenceStatuscomplete
DateCreated2000-12-01
DateModified2021-06-02

Ontological Relatives

GenesAxin1

GO terms

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GOName
GO:0000209 protein polyubiquitination
GO:0001701 in utero embryonic development
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002039 p53 binding
GO:0005102 signaling receptor binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0006913 nucleocytoplasmic transport
GO:0006915 apoptotic process
GO:0007605 sensory perception of sound
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0009950 dorsal/ventral axis specification
GO:0009953 dorsal/ventral pattern formation
GO:0010629 negative regulation of gene expression
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0014069 postsynaptic density
GO:0015630 microtubule cytoskeleton
GO:0016055 Wnt signaling pathway
GO:0016328 lateral plasma membrane
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0030159 signaling receptor complex adaptor activity
GO:0030163 protein catabolic process
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030877 beta-catenin destruction complex
GO:0031122 cytoplasmic microtubule organization
GO:0031398 positive regulation of protein ubiquitination
GO:0031410 cytoplasmic vesicle
GO:0031625 ubiquitin protein ligase binding
GO:0032147 activation of protein kinase activity
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032991 protein-containing complex
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0034622 cellular protein-containing complex assembly
GO:0036342 post-anal tail morphogenesis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043507 positive regulation of JUN kinase activity
GO:0043621 protein self-association
GO:0045599 negative regulation of fat cell differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0046332 SMAD binding
GO:0048318 axial mesoderm development
GO:0048320 axial mesoderm formation
GO:0048471 perinuclear region of cytoplasm
GO:0051248 negative regulation of protein metabolic process
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0060070 canonical Wnt signaling pathway
GO:0060090 molecular adaptor activity
GO:0060322 head development
GO:0060828 regulation of canonical Wnt signaling pathway
GO:0070016 armadillo repeat domain binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
GO:0071514 genetic imprinting
GO:0071944 cell periphery
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:1990909 Wnt signalosome
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process

Subcellular Location

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Subcellular Location
Cell membrane
Cytoplasm
Membrane
Nucleus

Domains

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DomainNameCategoryType
IPR001158 DIX domainDomainDomain
IPR014936 Axin beta-catenin bindingDomainDomain
IPR016137 RGS domainDomainDomain
IPR024066 RGS, subdomain 1/3FamilyHomologous superfamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR029797 Axin-1FamilyFamily
IPR032101 Axin-1/2, tankyrase-binding domainDomainDomain
IPR036305 RGS domain superfamilyFamilyHomologous superfamily
IPR038207 DIX domain superfamilyFamilyHomologous superfamily
IPR043581 Axin-likeFamilyFamily

Diseases

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Interactions

43 interactions

InteractorPartnerSourcesPublicationsLink
AXIN1_MOUSERN111_MOUSEBioGRID, MINT16601693 details
AXIN1_MOUSEGSK3A_HUMANBioGRID, IntAct20368287 details
AXIN1_MOUSEGSK3B_HUMANbhf-ucl, BioGRID, IntAct10330403 12421363 20368287 22682247 details
AXIN1_MOUSETNKS1_HUMANDIP19759537 details
AXIN1_MOUSEGSK3B_MOUSEbhf-ucl, BioGRID, MINT10318824 14734535 18316368 19107203 19581931 21242974 22682247 25331900 details
AXIN1_MOUSELRP5_MOUSEBioGRID, MINT11336703 19075000 19581931 details
AXIN1_MOUSECTNB1_MOUSEBioGRID, IntAct, UniProt10318824 12805222 17053159 18316368 21242974 22682247 24976009 25873176 details
AXIN1_MOUSEAPCL_HUMANBioGRID10330403 details
AXIN1_MOUSEAXIN1_MOUSEBioGRID12223491 15579909 18316368 9920888 details
AXIN1_MOUSEPP2AA_MOUSEBioGRID9920888 details
AXIN1_MOUSEM3K4_MOUSEBioGRID12878610 18316368 details
AXIN1_MOUSEKIF3A_MOUSEBioGRID22473005 details
AXIN1_MOUSENCK2_MOUSEBioGRID11557983 details
AXIN1_MOUSEANM1_MOUSEBioGRID21242974 details
AXIN1_MOUSEPIAS1_MOUSEBioGRID12223491 details
AXIN1_MOUSEPIAS2_MOUSEBioGRID12223491 details
AXIN1_MOUSEPIAS4_MOUSEBioGRID12223491 details
AXIN1_MOUSESMAD3_MOUSEBioGRID, MINT16601693 details
AXIN1_MOUSESMAD7_MOUSEBioGRID, MINT16601693 details
AXIN1_MOUSESMAD6_MOUSEBioGRID, MINT16601693 details
AXIN1_MOUSECTNB1_HUMANbhf-ucl, BioGRID, DIP, MINT10330403 12421363 18509060 20531388 details
AXIN1_MOUSEHD_MOUSEMINT20531388 details
AXIN1_MOUSEDAB2_MOUSEMINT, UniProt12805222 19581931 details
AXIN1_MOUSEPP1A_MOUSEMINT19581931 details
AXIN1_MOUSEDVL3_MOUSEUniProt12805222 details
AXIN1_MOUSELRP6_HUMANbhf-ucl12897152 19107203 details
AXIN1_MOUSEAIDA_MOUSEMINT25117763 details
AXIN1_MOUSEWWTR1_MOUSEIntAct24976009 details
AXIN1_MOUSEYAP1_HUMANIntAct24976009 details
AXIN1_MOUSETGIF1_HUMANIntAct25873176 details
AXIN1_MOUSEUBB_MOUSEDIP18509060 details
AXIN1_MOUSEUBC_MOUSEDIP18509060 details
AXIN1_MOUSERS27A_MOUSEDIP18509060 details
AXIN1_MOUSERL40_MOUSEDIP18509060 details
AXIN1_MOUSECADH2_MOUSEBioGRID19075000 details
AXIN1_MOUSERNF11_MOUSEBioGRID16601693 details
AXIN1_MOUSE2AAA_MOUSEBioGRID9920888 details
AXIN1_MOUSEDIXC1_MOUSEBioGRID15579909 details
AXIN1_MOUSEDVL2_MOUSEBioGRID15579909 details
AXIN1_MOUSECSN2_MOUSEBioGRID19576224 details
AXIN1_MOUSEP53_MOUSEBioGRID15526030 details
AXIN1_MOUSEHIPK2_MOUSEBioGRID15526030 details
AXIN1_MOUSEMP2K1_MOUSEBioGRID12223491 18316368 details