Entity Details

Primary name COMD1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8K4M5
EntryNameCOMD1_MOUSE
FullNameCOMM domain-containing protein 1
TaxID10090
Evidenceevidence at protein level
Length188
SequenceStatuscomplete
DateCreated2004-08-16
DateModified2021-06-02

Ontological Relatives

GenesCommd1

GO terms

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GOName
GO:0005507 copper ion binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005769 early endosome
GO:0005829 cytosol
GO:0006289 nucleotide-excision repair
GO:0006878 cellular copper ion homeostasis
GO:0006893 Golgi to plasma membrane transport
GO:0010008 endosome membrane
GO:0015031 protein transport
GO:0019871 sodium channel inhibitor activity
GO:0031398 positive regulation of protein ubiquitination
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031648 protein destabilization
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034383 low-density lipoprotein particle clearance
GO:0042632 cholesterol homeostasis
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0048227 plasma membrane to endosome transport
GO:0050750 low-density lipoprotein particle receptor binding
GO:0055037 recycling endosome
GO:0055070 copper ion homeostasis
GO:0070300 phosphatidic acid binding
GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
GO:0097006 regulation of plasma lipoprotein particle levels
GO:1902072 negative regulation of hypoxia-inducible factor-1alpha signaling pathway
GO:1902306 negative regulation of sodium ion transmembrane transport
GO:1904109 positive regulation of cholesterol import
GO:1905751 positive regulation of endosome to plasma membrane protein transport
GO:2000009 negative regulation of protein localization to cell surface
GO:2000010 positive regulation of protein localization to cell surface

Subcellular Location

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Subcellular Location
Cytoplasm
Cytoplasmic vesicle
Early endosome
Endosome membrane
Nucleus
Recycling endosome

Domains

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DomainNameCategoryType
IPR017920 COMM domainDomainDomain
IPR033776 COMMD1 N-terminal domainDomainDomain
IPR037351 COMM domain-containing protein 1FamilyFamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
COMD1_MOUSEFAIM1_HUMANBioGRID32015347 details
COMD1_MOUSETF65_HUMANMINT19270718 details