Entity Details

Primary name PLCE1_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8K4S1
EntryNamePLCE1_MOUSE
FullName1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
TaxID10090
Evidenceevidence at protein level
Length2282
SequenceStatuscomplete
DateCreated2006-10-31
DateModified2021-06-02

Ontological Relatives

GenesPlce1

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0000187 obsolete activation of MAPK activity
GO:0004435 phosphatidylinositol phospholipase C activity
GO:0004629 phospholipase C activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0006651 diacylglycerol biosynthetic process
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007186 G protein-coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0007265 Ras protein signal transduction
GO:0008277 regulation of G protein-coupled receptor signaling pathway
GO:0010592 positive regulation of lamellipodium assembly
GO:0016042 lipid catabolic process
GO:0019899 enzyme binding
GO:0030027 lamellipodium
GO:0031267 small GTPase binding
GO:0032835 glomerulus development
GO:0045859 regulation of protein kinase activity
GO:0046578 regulation of Ras protein signal transduction
GO:0046872 metal ion binding
GO:0048015 phosphatidylinositol-mediated signaling

Subcellular Location

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Subcellular Location
Cell membrane
Cell projection
Cytoplasm
Golgi apparatus membrane

Domains

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DomainNameCategoryType
IPR000008 C2 domainDomainDomain
IPR000159 Ras-associating (RA) domainDomainDomain
IPR000909 Phosphatidylinositol-specific phospholipase C, X domainDomainDomain
IPR001192 Phosphoinositide phospholipase C familyFamilyFamily
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domainDomainDomain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domainDomainDomain
IPR011992 EF-hand domain pairFamilyHomologous superfamily
IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domainDomainDomain
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamilyFamilyHomologous superfamily
IPR023578 Ras guanine nucleotide exchange factor domain superfamilyFamilyHomologous superfamily
IPR028398 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1FamilyFamily
IPR029071 Ubiquitin-like domain superfamilyFamilyHomologous superfamily
IPR035892 C2 domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

2 interactions

InteractorPartnerSourcesPublicationsLink
PLCE1_MOUSERASH_HUMANDIP24441586 details
PLCE1_MOUSERYR2_MOUSEIntAct23540699 details