Entity Details

Primary name SIR3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8R104
EntryNameSIR3_MOUSE
FullNameNAD-dependent protein deacetylase sirtuin-3
TaxID10090
Evidenceevidence at protein level
Length334
SequenceStatuscomplete
DateCreated2003-10-31
DateModified2021-06-02

Ontological Relatives

GenesSirt3

GO terms

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GOName
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
GO:0006476 protein deacetylation
GO:0008270 zinc ion binding
GO:0009060 aerobic respiration
GO:0016020 membrane
GO:0016740 transferase activity
GO:0017136 NAD-dependent histone deacetylase activity
GO:0019899 enzyme binding
GO:0032024 positive regulation of insulin secretion
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032991 protein-containing complex
GO:0034979 NAD-dependent protein deacetylase activity
GO:0034983 peptidyl-lysine deacetylation
GO:0043565 sequence-specific DNA binding
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070403 NAD+ binding
GO:0070932 histone H3 deacetylation
GO:1901671 positive regulation of superoxide dismutase activity
GO:1902553 positive regulation of catalase activity
GO:1903109 positive regulation of mitochondrial transcription
GO:2000304 positive regulation of ceramide biosynthetic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000757 negative regulation of peptidyl-lysine acetylation

Subcellular Location

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Subcellular Location
Cytoplasm
Mitochondrion matrix

Domains

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DomainNameCategoryType
IPR003000 Sirtuin familyFamilyFamily
IPR017328 Sirtuin, class IFamilyFamily
IPR026590 Sirtuin family, catalytic core domainDomainDomain
IPR026591 Sirtuin, catalytic core small domain superfamilyFamilyHomologous superfamily
IPR029035 DHS-like NAD/FAD-binding domain superfamilyFamilyHomologous superfamily

Diseases

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