Entity Details

Primary name DICER_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8R418
EntryNameDICER_MOUSE
FullNameEndoribonuclease Dicer
TaxID10090
Evidenceevidence at protein level
Length1916
SequenceStatuscomplete
DateCreated2002-10-25
DateModified2021-06-02

Ontological Relatives

GO terms

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GOName
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000212 meiotic spindle organization
GO:0001525 angiogenesis
GO:0001834 trophectodermal cell proliferation
GO:0001932 regulation of protein phosphorylation
GO:0001942 hair follicle development
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004521 endoribonuclease activity
GO:0004525 ribonuclease III activity
GO:0004530 deoxyribonuclease I activity
GO:0005524 ATP binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0006309 apoptotic DNA fragmentation
GO:0006396 RNA processing
GO:0007284 spermatogonial cell division
GO:0008283 cell population proliferation
GO:0008593 regulation of Notch signaling pathway
GO:0009791 post-embryonic development
GO:0010070 zygote asymmetric cell division
GO:0010468 regulation of gene expression
GO:0010626 negative regulation of Schwann cell proliferation
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010660 regulation of muscle cell apoptotic process
GO:0014040 positive regulation of Schwann cell differentiation
GO:0014835 myoblast differentiation involved in skeletal muscle regeneration
GO:0016075 rRNA catabolic process
GO:0016246 RNA interference
GO:0016442 RISC complex
GO:0019827 stem cell population maintenance
GO:0019904 protein domain specific binding
GO:0021522 spinal cord motor neuron differentiation
GO:0021675 nerve development
GO:0021889 olfactory bulb interneuron differentiation
GO:0021987 cerebral cortex development
GO:0030324 lung development
GO:0030326 embryonic limb morphogenesis
GO:0030422 production of siRNA involved in RNA interference
GO:0030423 targeting of mRNA for destruction involved in RNA interference
GO:0030424 axon
GO:0030425 dendrite
GO:0030426 growth cone
GO:0031054 pre-miRNA processing
GO:0031069 hair follicle morphogenesis
GO:0031508 pericentric heterochromatin assembly
GO:0031641 regulation of myelination
GO:0031643 positive regulation of myelination
GO:0032290 peripheral nervous system myelin formation
GO:0032720 negative regulation of tumor necrosis factor production
GO:0033168 conversion of ds siRNA to ss siRNA involved in RNA interference
GO:0035087 siRNA loading onto RISC involved in RNA interference
GO:0035116 embryonic hindlimb morphogenesis
GO:0035148 tube formation
GO:0035196 production of miRNAs involved in gene silencing by miRNA
GO:0035197 siRNA binding
GO:0035198 miRNA binding
GO:0035264 multicellular organism growth
GO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA
GO:0036404 conversion of ds siRNA to ss siRNA
GO:0038061 NIK/NF-kappaB signaling
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0045069 regulation of viral genome replication
GO:0045589 regulation of regulatory T cell differentiation
GO:0045595 regulation of cell differentiation
GO:0045664 regulation of neuron differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0048255 mRNA stabilization
GO:0048471 perinuclear region of cytoplasm
GO:0048536 spleen development
GO:0048565 digestive tract development
GO:0048608 reproductive structure development
GO:0048713 regulation of oligodendrocyte differentiation
GO:0048730 epidermis morphogenesis
GO:0048754 branching morphogenesis of an epithelial tube
GO:0048812 neuron projection morphogenesis
GO:0048856 anatomical structure development
GO:0050727 regulation of inflammatory response
GO:0050767 regulation of neurogenesis
GO:0051216 cartilage development
GO:0051225 spindle assembly
GO:0051252 regulation of RNA metabolic process
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:0055013 cardiac muscle cell development
GO:0060119 inner ear receptor cell development
GO:0060253 negative regulation of glial cell proliferation
GO:0060576 intestinal epithelial cell development
GO:0061309 cardiac neural crest cell development involved in outflow tract morphogenesis
GO:0061548 ganglion development
GO:0070062 extracellular exosome
GO:0070173 regulation of enamel mineralization
GO:0070578 RISC-loading complex
GO:0070883 pre-miRNA binding
GO:0071335 hair follicle cell proliferation
GO:0090501 RNA phosphodiester bond hydrolysis
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
GO:2000628 regulation of miRNA metabolic process
GO:2000630 positive regulation of miRNA metabolic process
GO:2000736 regulation of stem cell differentiation

Subcellular Location

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Subcellular Location
Cytoplasm

Domains

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DomainNameCategoryType
IPR000999 Ribonuclease III domainDomainDomain
IPR001650 Helicase, C-terminalDomainDomain
IPR003100 PAZ domainDomainDomain
IPR005034 Dicer dimerisation domainDomainDomain
IPR006935 Helicase/UvrB, N-terminalDomainDomain
IPR011907 Ribonuclease IIIFamilyFamily
IPR014001 Helicase superfamily 1/2, ATP-binding domainDomainDomain
IPR014720 Double-stranded RNA-binding domainDomainDomain
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR036085 PAZ domain superfamilyFamilyHomologous superfamily
IPR036389 Ribonuclease III, endonuclease domain superfamilyFamilyHomologous superfamily
IPR038248 Dicer dimerisation domain superfamilyFamilyHomologous superfamily
IPR044441 Dicer, double-stranded RNA-binding domainDomainDomain

Diseases

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Interactions

3 interactions