Entity Details

Primary name NLRP3_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8R4B8
EntryNameNLRP3_MOUSE
FullNameNACHT, LRR and PYD domains-containing protein 3
TaxID10090
Evidenceevidence at protein level
Length1033
SequenceStatuscomplete
DateCreated2003-03-28
DateModified2021-06-02

Ontological Relatives

GenesNlrp3

GO terms

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GOName
GO:0000139 Golgi membrane
GO:0002523 leukocyte migration involved in inflammatory response
GO:0002674 negative regulation of acute inflammatory response
GO:0002720 positive regulation of cytokine production involved in immune response
GO:0002830 positive regulation of type 2 immune response
GO:0005524 ATP binding
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005829 cytosol
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006954 inflammatory response
GO:0008134 transcription factor binding
GO:0014070 response to organic cyclic compound
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032691 negative regulation of interleukin-1 beta production
GO:0032731 positive regulation of interleukin-1 beta production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0042802 identical protein binding
GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043565 sequence-specific DNA binding
GO:0044546 NLRP3 inflammasome complex assembly
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0045630 positive regulation of T-helper 2 cell differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0050727 regulation of inflammatory response
GO:0050728 negative regulation of inflammatory response
GO:0050830 defense response to Gram-positive bacterium
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0071222 cellular response to lipopolysaccharide
GO:0071224 cellular response to peptidoglycan
GO:0072559 NLRP3 inflammasome complex
GO:1901223 negative regulation of NIK/NF-kappaB signaling
GO:2000321 positive regulation of T-helper 17 cell differentiation
GO:2000553 positive regulation of T-helper 2 cell cytokine production

Subcellular Location

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Subcellular Location
Cytoplasm
Endoplasmic reticulum
Inflammasome
Nucleus
Secreted

Domains

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DomainNameCategoryType
IPR001611 Leucine-rich repeatRepeatRepeat
IPR004020 DAPIN domainDomainDomain
IPR007111 NACHT nucleoside triphosphataseDomainDomain
IPR011029 Death-like domain superfamilyFamilyHomologous superfamily
IPR027417 P-loop containing nucleoside triphosphate hydrolaseFamilyHomologous superfamily
IPR029495 NACHT-associated domainDomainDomain
IPR032675 Leucine-rich repeat domain superfamilyFamilyHomologous superfamily
IPR041075 NOD2, winged helix domainDomainDomain
IPR041267 NACHT, LRR and PYD domains-containing protein, helical domain HD2DomainDomain

Diseases

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