Entity Details

Primary name FBXW7_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8VBV4
EntryNameFBXW7_MOUSE
FullNameF-box/WD repeat-containing protein 7
TaxID10090
Evidenceevidence at protein level
Length710
SequenceStatuscomplete
DateCreated2004-03-01
DateModified2021-06-02

Ontological Relatives

GenesFbxw7

GO terms

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GOName
GO:0001570 vasculogenesis
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0006974 cellular response to DNA damage stimulus
GO:0007062 sister chromatid cohesion
GO:0007219 Notch signaling pathway
GO:0010629 negative regulation of gene expression
GO:0010992 ubiquitin recycling
GO:0016021 integral component of membrane
GO:0016567 protein ubiquitination
GO:0019005 SCF ubiquitin ligase complex
GO:0030324 lung development
GO:0030332 cyclin binding
GO:0030674 protein-macromolecule adaptor activity
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0031398 positive regulation of protein ubiquitination
GO:0031625 ubiquitin protein ligase binding
GO:0031648 protein destabilization
GO:0032991 protein-containing complex
GO:0034644 cellular response to UV
GO:0042752 regulation of circadian rhythm
GO:0042802 identical protein binding
GO:0043130 ubiquitin binding
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045741 positive regulation of epidermal growth factor-activated receptor activity
GO:0048471 perinuclear region of cytoplasm
GO:0048511 rhythmic process
GO:0050816 phosphothreonine residue binding
GO:0050821 protein stabilization
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0090049 regulation of cell migration involved in sprouting angiogenesis
GO:0097027 ubiquitin-protein transferase activator activity
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1903146 regulation of autophagy of mitochondrion
GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903955 positive regulation of protein targeting to mitochondrion
GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:2000060 positive regulation of ubiquitin-dependent protein catabolic process
GO:2001205 negative regulation of osteoclast development

Subcellular Location

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Subcellular Location
Nucleus

Domains

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DomainNameCategoryType
IPR001680 WD40 repeatRepeatRepeat
IPR001810 F-box domainDomainDomain
IPR015943 WD40/YVTN repeat-like-containing domain superfamilyFamilyHomologous superfamily
IPR019775 WD40 repeat, conserved siteSiteConserved site
IPR020472 G-protein beta WD-40 repeatRepeatRepeat
IPR036047 F-box-like domain superfamilyFamilyHomologous superfamily
IPR036322 WD40-repeat-containing domain superfamilyFamilyHomologous superfamily

Diseases

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