Entity Details

Primary name HDAC8_MOUSE
Entity type UniProt
Source Source Link

Details

AccessionQ8VH37
EntryNameHDAC8_MOUSE
FullNameHistone deacetylase 8
TaxID10090
Evidenceevidence at protein level
Length377
SequenceStatuscomplete
DateCreated2003-04-11
DateModified2021-06-02

Ontological Relatives

GenesHdac8

GO terms

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GOName
GO:0000118 histone deacetylase complex
GO:0003682 chromatin binding
GO:0004407 histone deacetylase activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0006325 chromatin organization
GO:0007062 sister chromatid cohesion
GO:0008134 transcription factor binding
GO:0010629 negative regulation of gene expression
GO:0019213 deacetylase activity
GO:0030544 Hsp70 protein binding
GO:0031397 negative regulation of protein ubiquitination
GO:0031647 regulation of protein stability
GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0032204 regulation of telomere maintenance
GO:0035984 cellular response to trichostatin A
GO:0045668 negative regulation of osteoblast differentiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046872 metal ion binding
GO:0051879 Hsp90 protein binding
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071922 regulation of cohesin loading
GO:1903496 response to 11-deoxycorticosterone
GO:1904322 cellular response to forskolin
GO:2000616 negative regulation of histone H3-K9 acetylation

Subcellular Location

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Subcellular Location
Cytoplasm
Nucleus

Domains

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DomainNameCategoryType
IPR000286 Histone deacetylase familyFamilyFamily
IPR003084 Histone deacetylaseFamilyFamily
IPR023696 Ureohydrolase domain superfamilyFamilyHomologous superfamily
IPR023801 Histone deacetylase domainDomainDomain
IPR037138 Histone deacetylase domain superfamilyFamilyHomologous superfamily

Diseases

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Interactions

1 interaction

InteractorPartnerSourcesPublicationsLink
HDAC8_MOUSEERR1_MOUSEBioGRID20484414 details